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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HOXB3
Z-value: 1.98
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Transcription factors associated with HOXB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB3 | hg19_v2_chr17_-_46667628_46667642 | -0.91 | 8.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.3 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 3.1 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.2 | 2.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 1.9 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.2 | 1.7 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.2 | 1.6 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 1.5 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.3 | 1.4 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.1 | 1.3 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.3 | 1.2 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 1.8 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.2 | 1.6 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 1.3 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 1.1 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 0.7 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 0.5 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.3 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.0 | 4.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 3.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 1.7 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 1.7 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.2 | 1.6 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 1.2 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.0 | 0.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.3 | 0.8 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 1.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.0 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.9 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 0.5 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.5 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |