ISMARA results: HOMEZ

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HOMEZ

Z-value: 2.12

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Transcription factors associated with HOMEZ

Gene Symbol	Gene ID	Gene Info
HOMEZ Ensembl NCBI GeneCards UniProt	ENSG00000215271.6	homeobox and leucine zipper encoding

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOMEZ	hg19_v2_chr14_-_23762777_23762821	-0.85	1.5e-01	Click!

Activity profile of HOMEZ motif

Sorted Z-values of HOMEZ motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_164265984 Show fit	2.27	ENST00000511901.1	NPY1R Ensembl NCBI GeneCards UniProt Show fit	neuropeptide Y receptor Y1
chr7_+_30589829 Show fit	2.11	ENST00000579437.1	RP4-777O23.1 Ensembl NCBI GeneCards UniProt Show fit	RP4-777O23.1
chr1_+_81001398 Show fit	1.53	ENST00000418041.1 ENST00000443104.1	RP5-887A10.1 Ensembl NCBI GeneCards UniProt Show fit	RP5-887A10.1
chr7_-_7679633 Show fit	1.48	ENST00000401447.1	RPA3 Ensembl NCBI GeneCards UniProt Show fit	replication protein A3, 14kDa
chr1_+_63989004 Show fit	1.36	ENST00000371088.4	EFCAB7 Ensembl NCBI GeneCards UniProt Show fit	EF-hand calcium binding domain 7
chr19_+_29704142 Show fit	1.26	ENST00000587859.1 ENST00000590607.1	CTB-32O4.2 Ensembl NCBI GeneCards UniProt Show fit	CTB-32O4.2
chr12_+_100594557 Show fit	1.21	ENST00000546902.1 ENST00000552376.1 ENST00000551617.1	ACTR6 Ensembl NCBI GeneCards UniProt Show fit	ARP6 actin-related protein 6 homolog (yeast)
chrX_-_119709637 Show fit	1.16	ENST00000404115.3	CUL4B Ensembl NCBI GeneCards UniProt Show fit	cullin 4B
chr1_+_28099700 Show fit	1.10	ENST00000440806.2	STX12 Ensembl NCBI GeneCards UniProt Show fit	syntaxin 12
chr12_-_74686314 Show fit	1.08	ENST00000551210.1 ENST00000515416.2 ENST00000549905.1	RP11-81H3.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-81H3.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOMEZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0006293	nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.0	2.5	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	1.9	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	1.6	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	1.4	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.1	1.2	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	1.2	GO:0071539	protein localization to centrosome(GO:0071539)
0.0	1.1	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.0	1.0	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	1.0	GO:2000179	positive regulation of neural precursor cell proliferation(GO:2000179)

Showing 1 to 10 of 144 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.6	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	1.4	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	1.3	GO:0034451	centriolar satellite(GO:0034451)
0.2	1.2	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1	1.2	GO:0000836	Hrd1p ubiquitin ligase complex(GO:0000836)
0.1	1.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	1.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3	1.0	GO:0000818	nuclear MIS12/MIND complex(GO:0000818)
0.2	1.0	GO:0044530	supraspliceosomal complex(GO:0044530)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.3	GO:0001602	peptide YY receptor activity(GO:0001601) pancreatic polypeptide receptor activity(GO:0001602)
0.0	2.2	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	2.1	GO:0003684	damaged DNA binding(GO:0003684)
0.0	1.9	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	1.6	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	1.4	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.1	1.4	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1	1.2	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.1	1.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	1.0	GO:0033038	bitter taste receptor activity(GO:0033038)

Showing 1 to 10 of 112 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
1.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
1.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.8	PID AURORA B PATHWAY	Aurora B signaling
0.7	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.7	PID BARD1 PATHWAY	BARD1 signaling events
0.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.6	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	2.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	2.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	1.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	1.6	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	1.3	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	1.1	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	1.0	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.8	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination

Showing 1 to 10 of 31 entries

Results for HOMEZ

Z-value: 2.12

Motif logo

Transcription factors associated with HOMEZ

Activity-expression correlation:

Activity profile of HOMEZ motif

Sorted Z-values of HOMEZ motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOMEZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: