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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HNF4A
Z-value: 2.56
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Transcription factors associated with HNF4A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg19_v2_chr20_+_43029911_43029941 | 0.98 | 1.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.5 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 0.1 | 5.4 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.4 | 4.5 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.9 | 4.4 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.1 | 3.7 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 3.7 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 1.1 | 3.2 | GO:0035623 | renal glucose absorption(GO:0035623) |
| 0.1 | 3.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 3.1 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.4 | 2.8 | GO:0015811 | L-cystine transport(GO:0015811) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0005903 | brush border(GO:0005903) |
| 0.1 | 3.7 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 3.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 3.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 3.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 2.1 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 2.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 2.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 1.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.9 | 4.5 | GO:0030249 | cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249) |
| 0.9 | 4.4 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.5 | 4.3 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.7 | 3.7 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.3 | 3.2 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 3.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 3.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.4 | 2.8 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.5 | 2.7 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 3.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 3.2 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 2.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 0.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 4.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 3.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 3.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 3.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 2.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.8 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |