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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HMX2
Z-value: 1.14
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Transcription factors associated with HMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMX2 | hg19_v2_chr10_+_124907638_124907660 | -0.27 | 7.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_327537 Show fit | 1.41 |
ENST00000602735.1
|
interferon induced transmembrane protein 3 |
|
| chr11_+_5710919 Show fit | 1.26 |
ENST00000379965.3
ENST00000425490.1 |
tripartite motif containing 22 |
|
| chr22_+_50981079 Show fit | 1.19 |
ENST00000609268.1
|
CTA-384D8.34 |
|
| chr15_-_60695071 Show fit | 0.84 |
ENST00000557904.1
|
annexin A2 |
|
| chr19_-_3557570 Show fit | 0.62 |
ENST00000355415.2
|
major facilitator superfamily domain containing 12 |
|
| chr6_-_27858570 Show fit | 0.60 |
ENST00000359303.2
|
histone cluster 1, H3j |
|
| chr10_-_126849626 Show fit | 0.59 |
ENST00000530884.1
|
C-terminal binding protein 2 |
|
| chr15_+_101417919 Show fit | 0.52 |
ENST00000561338.1
|
aldehyde dehydrogenase 1 family, member A3 |
|
| chr1_-_202858227 Show fit | 0.51 |
ENST00000367262.3
|
RAB interacting factor |
|
| chr14_+_101295638 Show fit | 0.51 |
ENST00000523671.2
|
maternally expressed 3 (non-protein coding) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 1.3 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.2 | 0.8 | GO:0052362 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.1 | 0.8 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 0.7 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 0.5 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.2 | 0.5 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 0.5 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 0.5 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.5 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 0.8 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0044305 | calyx of Held(GO:0044305) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 0.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.7 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 0.5 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.2 | 0.5 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.0 | 0.5 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 0.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.4 | GO:0019863 | IgE binding(GO:0019863) |
| 0.1 | 0.4 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |