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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 1.77

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_662186780.653.5e-01Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_64014588 2.32 ENST00000371086.2
ENST00000340052.3
deleted in lymphocytic leukemia 2-like
chr16_+_53483983 1.69 ENST00000544545.1
retinoblastoma-like 2 (p130)
chr19_-_36297632 1.69 ENST00000588266.2
proline dehydrogenase (oxidase) 2
chr6_-_107230334 1.66 ENST00000607090.1
RP1-60O19.1
chr1_+_196621002 1.64 ENST00000367429.4
ENST00000439155.2
complement factor H
chr2_+_13677795 1.47 ENST00000434509.1
AC092635.1
chr6_-_32908792 1.35 ENST00000418107.2
major histocompatibility complex, class II, DM beta
chr13_+_50656307 1.31 ENST00000378180.4
deleted in lymphocytic leukemia 1 (non-protein coding)
chr15_+_58702742 1.25 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr16_+_66442411 1.21 ENST00000499966.1
long intergenic non-protein coding RNA 920
chr1_+_196621156 1.08 ENST00000359637.2
complement factor H
chr6_-_32908765 0.98 ENST00000416244.2
major histocompatibility complex, class II, DM beta
chrX_+_117480036 0.98 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
WD repeat domain 44
chr3_+_186501336 0.93 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
eukaryotic translation initiation factor 4A2
chr1_+_179263308 0.89 ENST00000426956.1
sterol O-acyltransferase 1
chr18_-_14132422 0.79 ENST00000589498.1
ENST00000590202.1
zinc finger protein 519
chr10_+_96305535 0.78 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
helicase, lymphoid-specific
chr13_+_51483814 0.75 ENST00000336617.3
ENST00000422660.1
ribonuclease H2, subunit B
chr1_+_227751231 0.73 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
zinc finger protein 678
chr9_-_115480303 0.72 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INTS3 and NABP interacting protein
chr14_-_94759595 0.71 ENST00000261994.4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_28836561 0.69 ENST00000419074.1
regulator of chromosome condensation 1
chr1_-_226374373 0.69 ENST00000366812.5
acyl-CoA binding domain containing 3
chr1_+_104104379 0.66 ENST00000435302.1
amylase, alpha 2B (pancreatic)
chr3_-_123680246 0.62 ENST00000488653.2
coiled-coil domain containing 14
chr6_-_136571400 0.61 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
mitochondrial fission regulator 2
chrX_-_135962876 0.61 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chr9_+_2157655 0.60 ENST00000452193.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_+_116892641 0.60 ENST00000487832.2
ENST00000518117.1
RWD domain containing 1
chr6_-_160209471 0.59 ENST00000539948.1
t-complex 1
chr14_-_94759361 0.59 ENST00000393096.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.59 ENST00000554723.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_48884002 0.57 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
chr7_-_102985035 0.56 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DnaJ (Hsp40) homolog, subfamily C, member 2
chr17_-_76220740 0.55 ENST00000600484.1
Uncharacterized protein
chr2_+_177134201 0.54 ENST00000452865.1
metaxin 2
chr10_+_86184676 0.51 ENST00000543283.1
coiled-coil serine-rich protein 2
chr5_-_102455801 0.50 ENST00000508629.1
ENST00000399004.2
gypsy retrotransposon integrase 1
chr1_+_2487631 0.50 ENST00000409119.1
tumor necrosis factor receptor superfamily, member 14
chr12_-_122750957 0.49 ENST00000451053.2
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr14_-_65409502 0.48 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr3_+_106959530 0.48 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
long intergenic non-protein coding RNA 883
chr9_+_42704004 0.47 ENST00000457288.1
COBW domain containing 7
chr6_+_111580508 0.47 ENST00000368847.4
KIAA1919
chr1_+_55464600 0.47 ENST00000371265.4
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr7_-_102985288 0.45 ENST00000379263.3
DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_82722225 0.42 ENST00000300515.8
golgin A6 family-like 9
chr19_-_38146289 0.42 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30 zinc finger protein
chr2_-_216257849 0.41 ENST00000456923.1
fibronectin 1
chr14_-_65409438 0.40 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr15_+_83098710 0.38 ENST00000561062.1
ENST00000358583.3
golgin A6 family-like 20
chr1_-_223988426 0.38 ENST00000391879.2
tumor protein p53 binding protein, 2
chr10_-_101673782 0.37 ENST00000422692.1
dynamin binding protein
chr2_+_170683979 0.37 ENST00000418381.1
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr2_+_177134134 0.36 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
metaxin 2
chr14_+_45553296 0.35 ENST00000355765.6
ENST00000553605.1
pre-mRNA processing factor 39
chr6_-_127664736 0.35 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
enoyl CoA hydratase domain containing 1
chr2_+_172543967 0.35 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
dynein, cytoplasmic 1, intermediate chain 2
chr15_-_32747835 0.32 ENST00000509311.2
ENST00000414865.2
golgin A8 family, member O
chrX_-_135962923 0.32 ENST00000565438.1
RNA binding motif protein, X-linked
chr14_+_99947715 0.32 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
cyclin K
chr14_+_88852059 0.31 ENST00000045347.7
spermatogenesis associated 7
chr15_+_84904525 0.31 ENST00000510439.2
golgin A6 family-like 4
chr18_+_11851383 0.30 ENST00000526991.2
charged multivesicular body protein 1B
chr2_+_120436733 0.29 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
transmembrane protein 177
chr15_+_28623784 0.29 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
golgin A8 family, member F
chr6_-_127664683 0.28 ENST00000528402.1
ENST00000454591.2
enoyl CoA hydratase domain containing 1
chr2_+_172544011 0.27 ENST00000508530.1
dynein, cytoplasmic 1, intermediate chain 2
chr15_-_70994612 0.27 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_172543919 0.26 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chr12_+_65996599 0.25 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
chr19_+_41882466 0.22 ENST00000436170.2
transmembrane protein 91
chr4_+_25378912 0.21 ENST00000510092.1
ENST00000505991.1
anaphase promoting complex subunit 4
chr15_+_43885252 0.21 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr9_+_104296122 0.21 ENST00000389120.3
ring finger protein 20, E3 ubiquitin protein ligase
chr12_-_8765446 0.21 ENST00000537228.1
ENST00000229335.6
activation-induced cytidine deaminase
chrX_-_77150985 0.20 ENST00000358075.6
magnesium transporter 1
chr3_+_106959552 0.20 ENST00000473550.1
long intergenic non-protein coding RNA 883
chr6_+_106535455 0.19 ENST00000424894.1
PR domain containing 1, with ZNF domain
chr10_-_36813162 0.19 ENST00000440465.1
nicotinamide phosphoribosyltransferase-like
chr2_+_172544182 0.18 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
dynein, cytoplasmic 1, intermediate chain 2
chr17_+_73230799 0.17 ENST00000579838.1
nucleoporin 85kDa
chr6_+_88106840 0.17 ENST00000369570.4
chromosome 6 open reading frame 164
chr19_-_1650666 0.15 ENST00000588136.1
transcription factor 3
chr3_+_193853927 0.15 ENST00000232424.3
hes family bHLH transcription factor 1
chr19_+_44455368 0.15 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
zinc finger protein 221
chr15_+_43985084 0.15 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr17_-_295730 0.14 ENST00000329099.4
family with sequence similarity 101, member B
chr21_+_38792602 0.14 ENST00000398960.2
ENST00000398956.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr15_-_74659978 0.10 ENST00000541301.1
ENST00000416978.1
ENST00000268053.6
cytochrome P450, family 11, subfamily A, polypeptide 1
chr6_+_123110302 0.10 ENST00000368440.4
sphingomyelin phosphodiesterase, acid-like 3A
chr12_+_59194154 0.09 ENST00000548969.1
Protein LOC100506869
chr11_-_130786400 0.09 ENST00000265909.4
sorting nexin 19
chr12_+_113587558 0.09 ENST00000335621.6
coiled-coil domain containing 42B
chr19_+_11457175 0.08 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
coiled-coil domain containing 159
chr2_+_120436760 0.08 ENST00000445518.1
ENST00000409951.1
transmembrane protein 177
chr12_+_21207503 0.07 ENST00000545916.1
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_-_43099070 0.05 ENST00000244336.5
carcinoembryonic antigen-related cell adhesion molecule 8
chr2_-_114461655 0.04 ENST00000424612.1
AC017074.2
chrX_-_7895755 0.03 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
patatin-like phospholipase domain containing 4
chr10_-_62332357 0.03 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_170683942 0.02 ENST00000272793.5
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr5_-_135290705 0.02 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr12_-_21757774 0.01 ENST00000261195.2
glycogen synthase 2 (liver)

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:2001190 peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4 1.9 GO:0008218 bioluminescence(GO:0008218)
0.3 0.8 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.2 1.7 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.2 1.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.2 0.8 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 2.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0044417 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.9 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.4 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 1.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 1.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.1 0.3 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.2 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0015074 DNA integration(GO:0015074)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.7 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.3 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.6 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.3 GO:0002945 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 0.9 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 0.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 0.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 2.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 2.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 3.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins