ISMARA results: HMGA2

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 1.77

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Transcription factors associated with HMGA2

Gene Symbol	Gene ID	Gene Info
HMGA2 Ensembl NCBI GeneCards UniProt	ENSG00000149948.9	high mobility group AT-hook 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMGA2	hg19_v2_chr12_+_66218598_66218678	0.65	3.5e-01	Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_64014588 Show fit	2.32	ENST00000371086.2 ENST00000340052.3	DLEU2L Ensembl NCBI GeneCards UniProt Show fit	deleted in lymphocytic leukemia 2-like
chr16_+_53483983 Show fit	1.69	ENST00000544545.1	RBL2 Ensembl NCBI GeneCards UniProt Show fit	retinoblastoma-like 2 (p130)
chr19_-_36297632 Show fit	1.69	ENST00000588266.2	PRODH2 Ensembl NCBI GeneCards UniProt Show fit	proline dehydrogenase (oxidase) 2
chr6_-_107230334 Show fit	1.66	ENST00000607090.1	RP1-60O19.1 Ensembl NCBI GeneCards UniProt Show fit	RP1-60O19.1
chr1_+_196621002 Show fit	1.64	ENST00000367429.4 ENST00000439155.2	CFH Ensembl NCBI GeneCards UniProt Show fit	complement factor H
chr2_+_13677795 Show fit	1.47	ENST00000434509.1	AC092635.1 Ensembl NCBI GeneCards UniProt Show fit	AC092635.1
chr6_-_32908792 Show fit	1.35	ENST00000418107.2	HLA-DMB Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DM beta
chr13_+_50656307 Show fit	1.31	ENST00000378180.4	DLEU1 Ensembl NCBI GeneCards UniProt Show fit	deleted in lymphocytic leukemia 1 (non-protein coding)
chr15_+_58702742 Show fit	1.25	ENST00000356113.6 ENST00000414170.3	LIPC Ensembl NCBI GeneCards UniProt Show fit	lipase, hepatic
chr16_+_66442411 Show fit	1.21	ENST00000499966.1	LINC00920 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 920

Showing 1 to 10 of 104 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.8	2.3	GO:2001190	peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4	1.9	GO:0008218	bioluminescence(GO:0008218)
0.2	1.7	GO:0006562	proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0	1.7	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	1.2	GO:0034372	very-low-density lipoprotein particle remodeling(GO:0034372)
0.1	1.1	GO:2000576	positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2	1.0	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
0.1	0.9	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0	0.9	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)

Showing 1 to 10 of 33 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0072562	blood microparticle(GO:0072562)
0.2	2.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	1.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	1.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.2	0.9	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.9	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3	0.8	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.8	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	0.7	GO:0070876	SOSS complex(GO:0070876)
0.0	0.6	GO:0071564	npBAF complex(GO:0071564)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	2.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	1.9	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	1.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	1.7	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.0	1.2	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	1.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	1.0	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.3	0.9	GO:0004772	sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0	0.9	GO:0004602	glutathione peroxidase activity(GO:0004602)

Showing 1 to 10 of 22 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	0.9	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.4	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	2.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.8	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	1.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	0.7	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins

Showing 1 to 8 of 8 entries

Results for HMGA2

Z-value: 1.77

Motif logo

Transcription factors associated with HMGA2

Activity-expression correlation:

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: