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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HMGA1
Z-value: 3.42
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Transcription factors associated with HMGA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA1 | hg19_v2_chr6_+_34204642_34204664 | -0.44 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_155484155 Show fit | 6.49 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr2_-_228244013 Show fit | 4.93 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
|
| chr12_-_71551652 Show fit | 4.71 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr7_-_35013217 Show fit | 4.05 |
ENST00000446375.1
|
dpy-19-like 1 (C. elegans) |
|
| chr4_+_155484103 Show fit | 3.63 |
ENST00000302068.4
|
fibrinogen beta chain |
|
| chr9_-_47314222 Show fit | 3.42 |
ENST00000420228.1
ENST00000438517.1 ENST00000414020.1 |
AL953854.2 |
|
| chrY_+_15418467 Show fit | 3.31 |
ENST00000595988.1
|
Uncharacterized protein |
|
| chr3_-_148939598 Show fit | 3.26 |
ENST00000455472.3
|
ceruloplasmin (ferroxidase) |
|
| chr1_-_197036364 Show fit | 2.83 |
ENST00000367412.1
|
coagulation factor XIII, B polypeptide |
|
| chr4_+_54927213 Show fit | 2.69 |
ENST00000595906.1
|
HCG2027126; Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.4 | 4.0 | GO:0018317 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.1 | 3.9 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.3 | 3.5 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 3.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 3.4 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.2 | 2.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 2.6 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.1 | 2.6 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.8 | 2.5 | GO:1905225 | response to thyrotropin-releasing hormone(GO:1905225) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 12.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 8.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 3.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 3.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 2.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.9 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 1.8 | GO:0022626 | cytosolic ribosome(GO:0022626) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 5.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 5.0 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.3 | 4.0 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 1.2 | 3.7 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 3.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 3.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 3.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.2 | 2.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.2 | 2.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 3.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.6 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.1 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 8.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 4.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 3.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 2.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 2.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |