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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HMBOX1
Z-value: 1.24
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Transcription factors associated with HMBOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMBOX1 | hg19_v2_chr8_+_28747884_28747938 | 0.62 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_57229155 Show fit | 0.83 |
ENST00000584089.1
|
spindle and kinetochore associated complex subunit 2 |
|
| chr10_+_115312766 Show fit | 0.79 |
ENST00000351270.3
|
hyaluronan binding protein 2 |
|
| chr22_-_37880543 Show fit | 0.75 |
ENST00000442496.1
|
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
|
| chr8_-_95220775 Show fit | 0.69 |
ENST00000441892.2
ENST00000521491.1 ENST00000027335.3 |
cadherin 17, LI cadherin (liver-intestine) |
|
| chr17_+_26638667 Show fit | 0.66 |
ENST00000600595.1
|
Uncharacterized protein |
|
| chr13_-_67802549 Show fit | 0.63 |
ENST00000328454.5
ENST00000377865.2 |
protocadherin 9 |
|
| chr13_+_44596471 Show fit | 0.57 |
ENST00000592085.1
ENST00000591799.1 |
long intergenic non-protein coding RNA 284 |
|
| chr6_-_107235331 Show fit | 0.56 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr12_-_51418549 Show fit | 0.56 |
ENST00000548150.1
|
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
|
| chr1_+_109632425 Show fit | 0.56 |
ENST00000338272.8
|
transmembrane protein 167B |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMBOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 0.7 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 0.6 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.6 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.0 | 0.5 | GO:0009650 | UV protection(GO:0009650) |
| 0.1 | 0.4 | GO:0045720 | negative regulation of integrin biosynthetic process(GO:0045720) |
| 0.1 | 0.4 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.4 | GO:2000843 | testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 0.1 | 0.4 | GO:0002155 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.4 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.3 | GO:0000126 | transcription factor TFIIIB complex(GO:0000126) |
| 0.0 | 0.3 | GO:0097513 | actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 0.8 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 0.7 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.1 | 0.6 | GO:0015087 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.5 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 0.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 0.4 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 0.4 | GO:0070546 | L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.1 | 0.4 | GO:0004882 | androgen receptor activity(GO:0004882) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |