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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HLF_TEF
Z-value: 1.25
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Transcription factors associated with HLF_TEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLF | hg19_v2_chr17_+_53343577_53343588 | 1.00 | 3.4e-03 | Click! |
| TEF | hg19_v2_chr22_+_41763274_41763337 | 0.92 | 7.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_158390282 Show fit | 1.79 |
ENST00000264265.3
|
latexin |
|
| chr1_+_154377669 Show fit | 1.30 |
ENST00000368485.3
ENST00000344086.4 |
interleukin 6 receptor |
|
| chr20_+_4666882 Show fit | 1.06 |
ENST00000379440.4
ENST00000430350.2 |
prion protein |
|
| chr3_+_186330712 Show fit | 1.00 |
ENST00000411641.2
ENST00000273784.5 |
alpha-2-HS-glycoprotein |
|
| chr17_+_70036164 Show fit | 0.97 |
ENST00000602013.1
|
Uncharacterized protein |
|
| chr1_+_7844312 Show fit | 0.95 |
ENST00000377541.1
|
period circadian clock 3 |
|
| chr8_-_27469383 Show fit | 0.85 |
ENST00000519742.1
|
clusterin |
|
| chr1_-_226496772 Show fit | 0.81 |
ENST00000359525.2
ENST00000460719.1 |
lin-9 homolog (C. elegans) |
|
| chr20_+_4667094 Show fit | 0.77 |
ENST00000424424.1
ENST00000457586.1 |
prion protein |
|
| chr8_-_27468842 Show fit | 0.76 |
ENST00000523500.1
|
clusterin |
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 2.0 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.6 | 1.8 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.1 | 1.8 | GO:0050961 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.3 | 1.4 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 1.0 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822) |
| 0.0 | 1.0 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.0 | 0.9 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.3 | 0.8 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.1 | 0.7 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.3 | 1.4 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 0.8 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.7 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 0.6 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.4 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.0 | 0.4 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 2.0 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.3 | 1.8 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 1.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.5 | 1.4 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.0 | 1.0 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.0 | 1.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.7 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.0 | 0.6 | GO:0008143 | poly(A) binding(GO:0008143) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.4 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.4 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.4 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.5 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.4 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |