ISMARA results: HIC2

Project

A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for HIC2

Z-value: 2.43

Motif logo

Transcription factors associated with HIC2

Gene Symbol	Gene ID	Gene Info
HIC2 Ensembl NCBI GeneCards UniProt	ENSG00000169635.5	HIC ZBTB transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC2	hg19_v2_chr22_+_21771656_21771693	0.72	2.8e-01	Click!

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_57310114 Show fit	1.67	ENST00000527972.1 ENST00000399154.2	SMTNL1 Ensembl NCBI GeneCards UniProt Show fit	smoothelin-like 1
chr17_+_73717516 Show fit	1.58	ENST00000200181.3 ENST00000339591.3	ITGB4 Ensembl NCBI GeneCards UniProt Show fit	integrin, beta 4
chr16_+_56642489 Show fit	1.57	ENST00000561491.1	MT2A Ensembl NCBI GeneCards UniProt Show fit	metallothionein 2A
chr17_+_73717551 Show fit	1.46	ENST00000450894.3	ITGB4 Ensembl NCBI GeneCards UniProt Show fit	integrin, beta 4
chr15_+_90735145 Show fit	1.38	ENST00000559792.1	SEMA4B Ensembl NCBI GeneCards UniProt Show fit	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr17_+_73717407 Show fit	1.33	ENST00000579662.1	ITGB4 Ensembl NCBI GeneCards UniProt Show fit	integrin, beta 4
chr3_+_32148106 Show fit	1.30	ENST00000425459.1 ENST00000431009.1	GPD1L Ensembl NCBI GeneCards UniProt Show fit	glycerol-3-phosphate dehydrogenase 1-like
chr8_-_145060593 Show fit	1.19	ENST00000313059.5 ENST00000524918.1 ENST00000313028.7 ENST00000525773.1	PARP10 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr19_-_55895966 Show fit	1.18	ENST00000444469.3	TMEM238 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 238
chr2_+_121493717 Show fit	1.15	ENST00000418323.1	GLI2 Ensembl NCBI GeneCards UniProt Show fit	GLI family zinc finger 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	GO:0035878	nail development(GO:0035878)
0.0	2.9	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.5	2.6	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0	2.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4	2.0	GO:0010847	regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.0	1.9	GO:0006958	complement activation, classical pathway(GO:0006958)
0.3	1.7	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.0	1.6	GO:0050919	negative chemotaxis(GO:0050919)
0.1	1.5	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.2	1.4	GO:0038195	urokinase plasminogen activator signaling pathway(GO:0038195)

Showing 1 to 10 of 488 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	2.8	GO:0030426	growth cone(GO:0030426)
0.0	2.1	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	2.0	GO:0044295	axonal growth cone(GO:0044295)
0.0	2.0	GO:0031430	M band(GO:0031430)
0.2	1.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	1.7	GO:0015030	Cajal body(GO:0015030)
0.0	1.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.5	GO:0031201	SNARE complex(GO:0031201)
0.1	1.4	GO:0071438	invadopodium membrane(GO:0071438)

Showing 1 to 10 of 152 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	3.4	GO:0038132	neuregulin binding(GO:0038132)
0.2	2.5	GO:0046870	cadmium ion binding(GO:0046870)
0.1	2.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	2.0	GO:0038191	neuropilin binding(GO:0038191)
0.0	2.0	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	1.9	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.1	1.8	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	1.8	GO:0005125	cytokine activity(GO:0005125)
0.6	1.7	GO:0008859	exoribonuclease II activity(GO:0008859)

Showing 1 to 10 of 314 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	1.6	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	1.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.4	PID RAS PATHWAY	Regulation of Ras family activation
0.0	1.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	1.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	5.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	2.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	2.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	2.2	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	1.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.5	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling

Showing 1 to 10 of 79 entries

Results for HIC2

Z-value: 2.43

Motif logo

Transcription factors associated with HIC2

Activity-expression correlation:

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: