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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HESX1
Z-value: 1.03
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Transcription factors associated with HESX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HESX1 | hg19_v2_chr3_-_57260377_57260549 | 0.47 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_145060593 Show fit | 1.00 |
ENST00000313059.5
ENST00000524918.1 ENST00000313028.7 ENST00000525773.1 |
poly (ADP-ribose) polymerase family, member 10 |
|
| chr12_-_121476750 Show fit | 0.90 |
ENST00000543677.1
|
2'-5'-oligoadenylate synthetase-like |
|
| chr22_+_18632666 Show fit | 0.66 |
ENST00000215794.7
|
ubiquitin specific peptidase 18 |
|
| chr10_-_101380121 Show fit | 0.60 |
ENST00000370495.4
|
solute carrier family 25 (mitochondrial iron transporter), member 28 |
|
| chr5_-_179780312 Show fit | 0.60 |
ENST00000253778.8
|
glutamine-fructose-6-phosphate transaminase 2 |
|
| chr2_-_61765732 Show fit | 0.57 |
ENST00000443240.1
ENST00000436018.1 |
exportin 1 (CRM1 homolog, yeast) |
|
| chr5_+_52285144 Show fit | 0.56 |
ENST00000296585.5
|
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
|
| chr1_-_40237020 Show fit | 0.55 |
ENST00000327582.5
|
3-oxoacid CoA transferase 2 |
|
| chr19_-_45579762 Show fit | 0.44 |
ENST00000303809.2
|
zinc finger protein 296 |
|
| chr11_-_4414880 Show fit | 0.43 |
ENST00000254436.7
ENST00000543625.1 |
tripartite motif containing 21 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HESX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.2 | 1.0 | GO:0010847 | regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.7 | GO:0015747 | urate transport(GO:0015747) |
| 0.2 | 0.6 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.2 | 0.6 | GO:0033341 | regulation of collagen binding(GO:0033341) |
| 0.1 | 0.6 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.0 | 0.6 | GO:0006048 | fructose 6-phosphate metabolic process(GO:0006002) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 0.6 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 0.4 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 0.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.2 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.1 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.0 | 0.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.1 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.1 | GO:0097361 | CIA complex(GO:0097361) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 0.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.7 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 0.6 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.1 | 0.6 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.0 | 0.6 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.0 | 0.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 0.5 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.0 | 0.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |