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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HDX

Z-value: 0.34

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_837574870.613.9e-01Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_139756791 0.60 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr6_+_144471643 0.30 ENST00000367568.4
STX11
syntaxin 11
chrX_+_100224676 0.29 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr12_+_10460417 0.19 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr2_+_169926047 0.15 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_+_149447783 0.11 ENST00000449013.1
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_87754887 0.11 ENST00000409054.1
ENST00000331944.6
ENST00000409139.1
LINC00152
long intergenic non-protein coding RNA 152
chr8_+_145065705 0.10 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr5_-_35230771 0.09 ENST00000342362.5
PRLR
prolactin receptor
chr10_-_21186144 0.09 ENST00000377119.1
NEBL
nebulette
chr14_+_79746249 0.07 ENST00000428277.2
NRXN3
neurexin 3
chr14_+_71788096 0.07 ENST00000557151.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr5_-_135290651 0.06 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr14_+_79745746 0.06 ENST00000281127.7
NRXN3
neurexin 3
chr10_-_14372870 0.06 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr5_-_135290705 0.06 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr5_-_35230649 0.06 ENST00000382002.5
PRLR
prolactin receptor
chr7_-_107883678 0.06 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr6_+_42584847 0.05 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr19_-_58485895 0.05 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr3_+_54157480 0.04 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_+_36602104 0.04 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr9_+_6215799 0.04 ENST00000417746.2
ENST00000456383.2
IL33
interleukin 33
chr9_+_35538616 0.04 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr1_-_159684371 0.04 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr1_-_11024258 0.04 ENST00000418570.2
C1orf127
chromosome 1 open reading frame 127
chr2_+_102758210 0.03 ENST00000450319.1
IL1R1
interleukin 1 receptor, type I
chr2_-_40657397 0.03 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_-_100565249 0.03 ENST00000495591.1
ENST00000383691.4
ENST00000466947.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_-_48866517 0.02 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr10_+_45406627 0.02 ENST00000389583.4
TMEM72
transmembrane protein 72
chr14_+_79745682 0.02 ENST00000557594.1
NRXN3
neurexin 3
chr1_+_75600567 0.02 ENST00000356261.3
LHX8
LIM homeobox 8
chr12_-_31743901 0.02 ENST00000354285.4
DENND5B
DENN/MADD domain containing 5B
chr5_-_41213607 0.01 ENST00000337836.5
ENST00000433294.1
C6
complement component 6
chr1_-_169680745 0.01 ENST00000236147.4
SELL
selectin L
chr1_+_47489240 0.01 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr1_+_84630352 0.01 ENST00000450730.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_+_27608490 0.01 ENST00000451261.2
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr7_-_135412925 0.01 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr8_+_24151620 0.01 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr7_+_144015218 0.01 ENST00000408951.1
OR2A1
olfactory receptor, family 2, subfamily A, member 1
chr2_+_128403720 0.01 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr13_+_24144796 0.00 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr18_+_29027696 0.00 ENST00000257189.4
DSG3
desmoglein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.3 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins