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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for GATA3
Z-value: 3.14
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg19_v2_chr10_+_8096631_8096660 | 0.77 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_62203808 Show fit | 3.47 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr11_+_57310114 Show fit | 3.07 |
ENST00000527972.1
ENST00000399154.2 |
smoothelin-like 1 |
|
| chr1_+_153330322 Show fit | 2.40 |
ENST00000368738.3
|
S100 calcium binding protein A9 |
|
| chr1_-_27998689 Show fit | 2.34 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr9_-_21077939 Show fit | 1.98 |
ENST00000380232.2
|
interferon, beta 1, fibroblast |
|
| chr17_-_34417479 Show fit | 1.98 |
ENST00000225245.5
|
chemokine (C-C motif) ligand 3 |
|
| chr7_-_139756791 Show fit | 1.95 |
ENST00000489809.1
|
poly (ADP-ribose) polymerase family, member 12 |
|
| chr19_-_49362621 Show fit | 1.82 |
ENST00000594195.1
ENST00000595867.1 |
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
|
| chr12_-_121476959 Show fit | 1.80 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr19_+_10197463 Show fit | 1.78 |
ENST00000590378.1
ENST00000397881.3 |
chromosome 19 open reading frame 66 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.0 | 5.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.4 | 4.9 | GO:0045343 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) |
| 0.1 | 3.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 3.7 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.3 | 3.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 3.0 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.1 | 2.6 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 2.6 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.1 | 2.6 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 4.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 4.3 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 4.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 3.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 2.4 | GO:0030128 | clathrin coat of endocytic vesicle(GO:0030128) |
| 0.0 | 2.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 7.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 6.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 4.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.4 | 3.7 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 3.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 3.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 3.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 2.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 2.6 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 4.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 3.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 3.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.7 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 2.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 3.8 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 3.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 2.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |