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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for FOXO3_FOXD2
Z-value: 1.58
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Transcription factors associated with FOXO3_FOXD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXD2 | hg19_v2_chr1_+_47901689_47901689 | 0.99 | 1.4e-02 | Click! |
| FOXO3 | hg19_v2_chr6_+_108977520_108977549 | 0.96 | 3.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_101841588 Show fit | 4.69 |
ENST00000370418.3
|
carboxypeptidase N, polypeptide 1 |
|
| chr12_-_71551652 Show fit | 4.21 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr17_-_46035187 Show fit | 3.23 |
ENST00000300557.2
|
proline rich 15-like |
|
| chr13_-_67802549 Show fit | 2.54 |
ENST00000328454.5
ENST00000377865.2 |
protocadherin 9 |
|
| chr12_-_71551868 Show fit | 2.52 |
ENST00000247829.3
|
tetraspanin 8 |
|
| chr14_-_94789663 Show fit | 2.50 |
ENST00000557225.1
ENST00000341584.3 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
|
| chr17_-_64225508 Show fit | 2.19 |
ENST00000205948.6
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr2_+_26785409 Show fit | 2.07 |
ENST00000329615.3
ENST00000409392.1 |
chromosome 2 open reading frame 70 |
|
| chr3_+_186330712 Show fit | 1.94 |
ENST00000411641.2
ENST00000273784.5 |
alpha-2-HS-glycoprotein |
|
| chr5_-_142783175 Show fit | 1.81 |
ENST00000231509.3
ENST00000394464.2 |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO3_FOXD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 1.6 | 4.7 | GO:0030070 | insulin processing(GO:0030070) |
| 0.3 | 3.9 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.3 | 3.1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.1 | 3.1 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.2 | 2.8 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.3 | 2.4 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.0 | 2.0 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 1.9 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.3 | 1.8 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 2.6 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.1 | 2.3 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 2.1 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.1 | 1.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 1.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.3 | 1.6 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.3 | 1.6 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.2 | 1.5 | GO:0097149 | centralspindlin complex(GO:0097149) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 4.3 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 4.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 3.9 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 2.3 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 2.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.7 | 2.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.2 | 2.1 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.0 | 1.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 3.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.0 | REACTOME PI3K AKT ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.1 | 2.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.9 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |