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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for FOXM1_TBL1XR1
Z-value: 1.93
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg19_v2_chr3_-_176914191_176914235 | -0.96 | 4.1e-02 | Click! |
| FOXM1 | hg19_v2_chr12_-_2986107_2986258 | -0.67 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_5710919 Show fit | 1.84 |
ENST00000379965.3
ENST00000425490.1 |
tripartite motif containing 22 |
|
| chr10_+_91152303 Show fit | 1.58 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chrX_-_80457385 Show fit | 1.56 |
ENST00000451455.1
ENST00000436386.1 ENST00000358130.2 |
high mobility group nucleosome binding domain 5 |
|
| chr10_+_91092241 Show fit | 1.36 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_91087651 Show fit | 1.23 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr13_+_108921977 Show fit | 1.18 |
ENST00000430559.1
ENST00000375887.4 |
tumor necrosis factor (ligand) superfamily, member 13b |
|
| chr10_+_91061712 Show fit | 1.09 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr19_-_54824344 Show fit | 1.08 |
ENST00000346508.3
ENST00000446712.3 ENST00000432233.3 ENST00000301219.3 |
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 |
|
| chr12_+_75874580 Show fit | 1.02 |
ENST00000456650.3
|
GLI pathogenesis-related 1 |
|
| chr19_-_49371711 Show fit | 0.94 |
ENST00000355496.5
ENST00000263265.6 |
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.3 | 4.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.1 | 3.3 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.1 | 2.0 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.1 | 1.7 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 1.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 1.6 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 1.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.3 | 1.3 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 1.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 2.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.7 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 1.4 | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 1.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.2 | 1.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 1.1 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.0 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.0 | 1.0 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 3.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 2.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 2.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 2.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.9 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.0 | 1.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 1.6 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 1.5 | GO:0061135 | endopeptidase regulator activity(GO:0061135) |
| 0.0 | 1.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 1.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 2.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |