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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for FOXC1
Z-value: 0.87
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Transcription factors associated with FOXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXC1 | hg19_v2_chr6_+_1610681_1610681 | -0.94 | 6.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_23261589 Show fit | 0.98 |
ENST00000524168.1
ENST00000523833.2 ENST00000519243.1 ENST00000389131.3 |
lysyl oxidase-like 2 |
|
| chr2_+_66918558 Show fit | 0.94 |
ENST00000435389.1
ENST00000428590.1 ENST00000412944.1 |
AC007392.3 |
|
| chr22_+_46449674 Show fit | 0.85 |
ENST00000381051.2
|
hsa-mir-4763 |
|
| chr6_+_84563295 Show fit | 0.79 |
ENST00000369687.1
|
ripply transcriptional repressor 2 |
|
| chr12_-_12714006 Show fit | 0.72 |
ENST00000541207.1
|
dual specificity phosphatase 16 |
|
| chr3_-_139195350 Show fit | 0.71 |
ENST00000232217.2
|
retinol binding protein 2, cellular |
|
| chr8_-_123793048 Show fit | 0.61 |
ENST00000607710.1
|
RP11-44N11.2 |
|
| chr7_-_27219849 Show fit | 0.58 |
ENST00000396344.4
|
homeobox A10 |
|
| chr11_+_130184888 Show fit | 0.56 |
ENST00000602376.1
ENST00000532116.3 ENST00000602310.1 |
RP11-121M22.1 |
|
| chr15_+_63188009 Show fit | 0.55 |
ENST00000557900.1
|
RP11-1069G10.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.2 | 1.0 | GO:0018277 | protein deamination(GO:0018277) |
| 0.1 | 0.8 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.1 | 0.7 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.1 | 0.7 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.6 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.6 | GO:0060065 | uterus development(GO:0060065) |
| 0.2 | 0.5 | GO:0045081 | negative regulation of interleukin-10 biosynthetic process(GO:0045081) |
| 0.1 | 0.5 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.0 | 0.5 | GO:0051451 | myoblast migration(GO:0051451) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.2 | 0.6 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 0.6 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 0.5 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.5 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 0.4 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 0.4 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 0.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.0 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 0.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.5 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 0.4 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.0 | 0.4 | GO:0005497 | androgen binding(GO:0005497) |
| 0.0 | 0.4 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 0.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.3 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |