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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for FOSB
Z-value: 1.29
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Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg19_v2_chr19_+_45973360_45973523 | -0.69 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_176923803 Show fit | 1.39 |
ENST00000506161.1
|
PDZ and LIM domain 7 (enigma) |
|
| chr6_-_35888858 Show fit | 1.37 |
ENST00000507909.1
|
SRSF protein kinase 1 |
|
| chr11_-_102668879 Show fit | 1.36 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr5_-_176923846 Show fit | 1.28 |
ENST00000506537.1
|
PDZ and LIM domain 7 (enigma) |
|
| chr19_-_47128294 Show fit | 1.16 |
ENST00000596260.1
ENST00000597185.1 ENST00000598865.1 ENST00000594275.1 ENST00000291294.2 |
prostaglandin I2 (prostacyclin) receptor (IP) |
|
| chr19_-_36019123 Show fit | 1.14 |
ENST00000588674.1
ENST00000452271.2 ENST00000518157.1 |
suprabasin |
|
| chr19_-_55881741 Show fit | 1.09 |
ENST00000264563.2
ENST00000590625.1 ENST00000585513.1 |
interleukin 11 |
|
| chr14_+_77425972 Show fit | 1.07 |
ENST00000553613.1
|
RP11-7F17.7 |
|
| chr3_-_48601206 Show fit | 1.05 |
ENST00000273610.3
|
urocortin 2 |
|
| chr17_+_7482785 Show fit | 0.96 |
ENST00000250092.6
ENST00000380498.6 ENST00000584502.1 |
CD68 molecule |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.1 | 1.9 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 1.6 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.2 | 1.5 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 1.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 1.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 1.2 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.2 | 1.1 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.0 | 1.1 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 1.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 1.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 1.2 | GO:0044453 | nuclear membrane part(GO:0044453) |
| 0.1 | 0.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.9 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.8 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 0.7 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.0 | 0.7 | GO:0042599 | lamellar body(GO:0042599) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 1.8 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.2 | 1.3 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.1 | 1.2 | GO:0004955 | prostaglandin receptor activity(GO:0004955) |
| 0.0 | 1.1 | GO:0043495 | protein anchor(GO:0043495) |
| 0.3 | 1.0 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.1 | 0.9 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 0.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 3.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 2.1 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 1.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.2 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 1.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.1 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.8 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 1.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 1.2 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.8 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |