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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for EZH2
Z-value: 2.05
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148580563_148580601 | 0.56 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_34628104 Show fit | 1.98 |
ENST00000378909.2
|
AT rich interactive domain 3C (BRIGHT-like) |
|
| chr9_+_131902346 Show fit | 1.41 |
ENST00000432124.1
ENST00000435305.1 |
protein phosphatase 2A activator, regulatory subunit 4 |
|
| chr11_-_44331679 Show fit | 1.01 |
ENST00000329255.3
|
ALX homeobox 4 |
|
| chr17_+_7533439 Show fit | 0.85 |
ENST00000441599.2
ENST00000380450.4 ENST00000416273.3 ENST00000575903.1 ENST00000576830.1 ENST00000571153.1 ENST00000575618.1 ENST00000576152.1 |
sex hormone-binding globulin |
|
| chr15_+_91416092 Show fit | 0.83 |
ENST00000559353.1
|
furin (paired basic amino acid cleaving enzyme) |
|
| chr13_-_34250861 Show fit | 0.82 |
ENST00000445227.1
ENST00000454681.2 |
RP11-141M1.3 |
|
| chr5_+_175298573 Show fit | 0.79 |
ENST00000512824.1
|
complexin 2 |
|
| chr7_+_69064566 Show fit | 0.78 |
ENST00000403018.2
|
autism susceptibility candidate 2 |
|
| chr7_-_41740181 Show fit | 0.77 |
ENST00000442711.1
|
inhibin, beta A |
|
| chr2_+_121493717 Show fit | 0.77 |
ENST00000418323.1
|
GLI family zinc finger 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.2 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 1.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 0.9 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.0 | 0.9 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.0 | 0.9 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.9 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.3 | 0.8 | GO:0019082 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.3 | 0.8 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.3 | 0.8 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 1.0 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 1.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 1.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.9 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.9 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.8 | GO:0097169 | NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169) protease inhibitor complex(GO:0097179) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 1.2 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.1 | 1.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 1.0 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.0 | 1.0 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 1.0 | GO:0001848 | complement binding(GO:0001848) |
| 0.2 | 0.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 0.8 | GO:0005497 | androgen binding(GO:0005497) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.8 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.8 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.9 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.9 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 0.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |