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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ETV1_ERF_FEV_ELF1
Z-value: 1.20
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Transcription factors associated with ETV1_ERF_FEV_ELF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000006468.9 | ETS variant transcription factor 1 | |
| ENSG00000105722.5 | ETS2 repressor factor | |
| ENSG00000163497.2 | FEV transcription factor, ETS family member | |
| ENSG00000120690.9 | E74 like ETS transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV1 | hg19_v2_chr7_-_14026063_14026091 | -0.77 | 2.3e-01 | Click! |
| ELF1 | hg19_v2_chr13_-_41593425_41593480 | -0.47 | 5.3e-01 | Click! |
| FEV | hg19_v2_chr2_-_219850277_219850379 | 0.39 | 6.1e-01 | Click! |
| ERF | hg19_v2_chr19_-_42759300_42759324 | -0.26 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV1_ERF_FEV_ELF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 1.9 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.4 | 1.8 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.1 | 1.6 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.2 | 1.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 1.4 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
| 0.0 | 1.4 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.4 | GO:1903214 | regulation of protein targeting to mitochondrion(GO:1903214) |
| 0.1 | 1.3 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.7 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.3 | GO:0097526 | spliceosomal tri-snRNP complex(GO:0097526) |
| 0.1 | 1.2 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.0 | 1.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.4 | 1.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 1.0 | GO:1902560 | GMP reductase complex(GO:1902560) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.6 | 1.8 | GO:0008413 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539) |
| 0.0 | 1.6 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.2 | 1.5 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.3 | 1.4 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.1 | 1.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.4 | 1.1 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.1 | 1.1 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.2 | 1.0 | GO:0044715 | 8-oxo-dGDP phosphatase activity(GO:0044715) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.1 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.0 | 2.1 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.5 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 1.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 1.2 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 1.1 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |