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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ESRRA_ESR2
Z-value: 2.79
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | -0.91 | 8.6e-02 | Click! |
| ESRRA | hg19_v2_chr11_+_64073699_64073918 | -0.74 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.0 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 5.8 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.5 | 5.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 5.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 4.9 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
| 0.4 | 4.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.1 | 4.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 4.6 | GO:0045907 | positive regulation of vasoconstriction(GO:0045907) |
| 0.3 | 3.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.1 | 3.4 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 5.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 5.0 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 4.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.4 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 3.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 2.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 2.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 2.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 14.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 8.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 6.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 6.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 5.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 4.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 4.0 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.0 | 4.0 | GO:0005516 | calmodulin binding(GO:0005516) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 5.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.1 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 3.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.9 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 8.0 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 4.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 4.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 4.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 4.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |