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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for EMX2
Z-value: 2.00
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Transcription factors associated with EMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX2 | hg19_v2_chr10_+_119302508_119302559 | -0.70 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.2 | 3.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 3.2 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.1 | 2.8 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 2.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.6 | 2.4 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.5 | 1.4 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.2 | 1.4 | GO:0071725 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 1.3 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.0 | 1.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.5 | 3.5 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 3.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 1.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 1.3 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.0 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.9 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.6 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 3.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 1.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 1.4 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.1 | 1.4 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.3 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 1.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.2 | GO:0070915 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 1.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.9 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 2.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.5 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 1.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 0.8 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 0.8 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |