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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 2.29
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.9 | ETS transcription factor ELK4 | |
| ENSG00000244405.3 | ETS variant transcription factor 5 | |
| ENSG00000126767.13 | ETS transcription factor ELK1 | |
| ENSG00000111145.3 | ETS transcription factor ELK3 | |
| ENSG00000102034.12 | E74 like ETS transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELK4 | hg19_v2_chr1_-_205601064_205601090 | 0.99 | 7.5e-03 | Click! |
| ELK1 | hg19_v2_chrX_-_47509994_47510008 | 0.97 | 3.2e-02 | Click! |
| ELK3 | hg19_v2_chr12_+_96588368_96588394 | 0.96 | 4.0e-02 | Click! |
| ELF4 | hg19_v2_chrX_-_129244454_129244488 | -0.70 | 3.0e-01 | Click! |
| ETV5 | hg19_v2_chr3_-_185826286_185826464 | -0.43 | 5.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.8 | 5.1 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.1 | 5.0 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.2 | 4.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.5 | 3.9 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.3 | 3.8 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 3.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.4 | 3.6 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.2 | 3.6 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.2 | 3.5 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 9.2 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 4.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 4.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 3.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.6 | 3.8 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.3 | 3.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 3.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 3.1 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 3.0 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 6.1 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.3 | 4.8 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.0 | 4.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.5 | 4.4 | GO:0004324 | ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731) |
| 0.1 | 4.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 4.3 | GO:0034062 | RNA polymerase activity(GO:0034062) |
| 0.1 | 4.1 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 3.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 3.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.2 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 11.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 7.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.8 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 2.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 2.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 12.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 11.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 9.0 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.2 | 4.9 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.2 | 4.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 4.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.1 | 3.9 | REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | Genes involved in E2F mediated regulation of DNA replication |
| 0.1 | 3.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 3.7 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |