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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for E2F7_E2F1
Z-value: 3.74
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.94 | 5.9e-02 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.88 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.3 | 6.1 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 5.7 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.3 | 3.8 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.3 | 3.8 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.6 | 3.7 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.1 | 3.5 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) |
| 0.1 | 2.8 | GO:0006206 | pyrimidine nucleobase metabolic process(GO:0006206) |
| 0.9 | 2.7 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.2 | 2.7 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 6.9 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.8 | 6.8 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.4 | 5.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.2 | 5.5 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 3.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 3.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 3.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.7 | 2.7 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.5 | 2.7 | GO:0032301 | MutSalpha complex(GO:0032301) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.2 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 5.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 4.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.3 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.4 | 4.0 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 3.5 | GO:0035173 | histone kinase activity(GO:0035173) |
| 1.1 | 3.2 | GO:0004772 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.3 | 2.9 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.5 | 2.7 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.3 | 2.7 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 11.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 6.2 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 5.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 3.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 3.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 3.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.6 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 8.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 8.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 6.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 4.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.1 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 3.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 2.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 2.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |