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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for E2F6
Z-value: 1.61
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11605966_11606005 | -0.74 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_66461175 Show fit | 0.88 |
ENST00000536005.2
ENST00000299694.8 ENST00000561796.1 |
brain expressed, associated with NEDD4, 1 |
|
| chr10_-_126849626 Show fit | 0.86 |
ENST00000530884.1
|
C-terminal binding protein 2 |
|
| chr11_-_59436453 Show fit | 0.83 |
ENST00000300146.9
|
protein associated with topoisomerase II homolog 1 (yeast) |
|
| chr1_+_113217309 Show fit | 0.81 |
ENST00000544796.1
ENST00000369644.1 |
Mov10, Moloney leukemia virus 10, homolog (mouse) |
|
| chr8_-_145086922 Show fit | 0.81 |
ENST00000530478.1
|
poly (ADP-ribose) polymerase family, member 10 |
|
| chr6_+_83073952 Show fit | 0.78 |
ENST00000543496.1
|
trophoblast glycoprotein |
|
| chr16_-_11350036 Show fit | 0.77 |
ENST00000332029.2
|
suppressor of cytokine signaling 1 |
|
| chr15_+_41221536 Show fit | 0.68 |
ENST00000249749.5
|
delta-like 4 (Drosophila) |
|
| chr7_+_143078379 Show fit | 0.67 |
ENST00000449630.1
ENST00000457235.1 |
zyxin |
|
| chr2_-_178129551 Show fit | 0.65 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.3 | 1.6 | GO:0061074 | regulation of neural retina development(GO:0061074) |
| 0.2 | 1.2 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 1.2 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 1.1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.1 | 0.9 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.1 | 0.9 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.1 | 0.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.0 | 0.9 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.9 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.8 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.3 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 1.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.0 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 0.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.9 | GO:0032059 | bleb(GO:0032059) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 1.6 | GO:0019783 | ubiquitin-like protein-specific protease activity(GO:0019783) |
| 0.0 | 1.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 1.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.2 | 1.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.2 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 1.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 1.1 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 1.0 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 1.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.9 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.9 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.4 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 1.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.9 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 0.8 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |