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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for E2F2_E2F5
Z-value: 3.60
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | 0.95 | 5.0e-02 | Click! |
| E2F5 | hg19_v2_chr8_+_86089619_86089653 | 0.65 | 3.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 7.9 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.5 | 7.0 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 1.1 | 4.4 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.6 | 4.4 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.3 | 4.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.2 | 3.6 | GO:0071140 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 0.3 | 3.0 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.2 | 2.8 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.8 | 2.5 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.1 | 2.4 | GO:0015695 | organic cation transport(GO:0015695) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 7.9 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 7.5 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.3 | 3.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 3.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 3.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 3.0 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.2 | 2.9 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 2.6 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.0 | 2.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 2.5 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.9 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 6.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.9 | 4.4 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.0 | 4.0 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 3.6 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.0 | 3.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.4 | 3.3 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 3.3 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 3.0 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.2 | 2.9 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 8.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 6.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 4.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.2 | 4.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 3.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 3.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 2.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 7.9 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.2 | 5.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 5.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 4.8 | REACTOME GLOBAL GENOMIC NER GG NER | Genes involved in Global Genomic NER (GG-NER) |
| 0.1 | 3.4 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 2.9 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.1 | 2.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 2.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |