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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for DRGX_PROP1
Z-value: 1.26
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Transcription factors associated with DRGX_PROP1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_155484103 Show fit | 3.10 |
ENST00000302068.4
|
fibrinogen beta chain |
|
| chr4_+_155484155 Show fit | 2.89 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr3_-_195310802 Show fit | 2.34 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr8_-_95229531 Show fit | 1.91 |
ENST00000450165.2
|
cadherin 17, LI cadherin (liver-intestine) |
|
| chr6_+_26087646 Show fit | 1.56 |
ENST00000309234.6
|
hemochromatosis |
|
| chr10_+_115312766 Show fit | 1.47 |
ENST00000351270.3
|
hyaluronan binding protein 2 |
|
| chr6_-_32908792 Show fit | 1.39 |
ENST00000418107.2
|
major histocompatibility complex, class II, DM beta |
|
| chr6_-_107235331 Show fit | 1.32 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr1_-_200379180 Show fit | 1.32 |
ENST00000294740.3
|
zinc finger protein 281 |
|
| chr1_-_151148492 Show fit | 1.31 |
ENST00000295314.4
|
tropomodulin 4 (muscle) |
Network of associatons between targets according to the STRING database.
First level regulatory network of DRGX_PROP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.0 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.8 | 2.4 | GO:2001190 | peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.6 | 2.3 | GO:2000097 | negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 2.0 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.4 | 1.9 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 1.7 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.5 | 1.6 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641) |
| 0.4 | 1.2 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.2 | 1.0 | GO:0060133 | somatotropin secreting cell development(GO:0060133) |
| 0.1 | 1.0 | GO:0015811 | L-cystine transport(GO:0015811) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 2.5 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.2 | 2.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.0 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 1.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 1.6 | GO:1990357 | terminal web(GO:1990357) |
| 0.4 | 1.2 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 0.7 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 2.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 2.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 2.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.6 | 1.9 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.2 | 1.6 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 1.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.0 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 0.8 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |