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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for DMBX1

Z-value: 0.99

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_46972669-0.996.6e-03Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_220252068 0.83 ENST00000430206.1
ENST00000429013.1
DNPEP
aspartyl aminopeptidase
chr17_+_4643337 0.75 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr5_+_71403280 0.67 ENST00000511641.2
MAP1B
microtubule-associated protein 1B
chr12_-_76461249 0.60 ENST00000551524.1
NAP1L1
nucleosome assembly protein 1-like 1
chr17_-_4643161 0.59 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr10_-_101491828 0.59 ENST00000370483.5
ENST00000016171.5
COX15
cytochrome c oxidase assembly homolog 15 (yeast)
chr1_-_143913143 0.56 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr14_+_50234309 0.54 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr1_+_81001398 0.53 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
RP5-887A10.1
chr17_+_68100989 0.50 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_-_19651598 0.50 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr4_+_124571409 0.48 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
RP11-93L9.1
long intergenic non-protein coding RNA 1091
chr15_-_60771280 0.46 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NARG2
NMDA receptor regulated 2
chr2_-_220252530 0.46 ENST00000521459.1
DNPEP
aspartyl aminopeptidase
chr6_+_10585979 0.45 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_-_14541060 0.44 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr17_-_4643114 0.44 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr5_-_54988448 0.44 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr15_+_93443419 0.41 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr17_+_4643300 0.40 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr3_+_136649311 0.39 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr6_-_33297013 0.38 ENST00000453407.1
DAXX
death-domain associated protein
chr1_+_35734562 0.37 ENST00000314607.6
ENST00000373297.2
ZMYM4
zinc finger, MYM-type 4
chr22_+_31002990 0.37 ENST00000423350.1
TCN2
transcobalamin II
chr1_+_206138457 0.37 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr11_-_45940343 0.36 ENST00000532681.1
PEX16
peroxisomal biogenesis factor 16
chr17_-_48207157 0.36 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr2_-_175711133 0.35 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr7_-_135412925 0.35 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr6_-_111927062 0.34 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr3_-_121468513 0.32 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr8_-_125577940 0.30 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr3_-_121468602 0.30 ENST00000340645.5
GOLGB1
golgin B1
chr4_+_41937131 0.28 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr7_-_17500294 0.28 ENST00000439046.1
AC019117.2
AC019117.2
chr17_-_19651654 0.28 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr8_-_110656995 0.26 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr1_+_120839005 0.25 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr17_+_68101117 0.25 ENST00000587698.1
ENST00000587892.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_-_19651668 0.25 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr9_+_74920408 0.25 ENST00000451152.1
RP11-63P12.6
RP11-63P12.6
chr6_+_89791507 0.24 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr10_+_74451883 0.24 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr9_+_74920335 0.23 ENST00000451596.2
ENST00000436054.1
RP11-63P12.6
RP11-63P12.6
chr1_+_180875711 0.23 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr6_+_130339710 0.22 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr4_-_54232144 0.22 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr2_+_37571845 0.22 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr12_-_49581152 0.21 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr7_+_21582638 0.20 ENST00000409508.3
ENST00000328843.6
DNAH11
dynein, axonemal, heavy chain 11
chr2_-_165812028 0.20 ENST00000303735.4
SLC38A11
solute carrier family 38, member 11
chr12_-_110937351 0.20 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr18_+_52258390 0.17 ENST00000321600.1
DYNAP
dynactin associated protein
chr3_-_49058479 0.16 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr11_+_61248583 0.16 ENST00000432063.2
ENST00000338608.2
PPP1R32
protein phosphatase 1, regulatory subunit 32
chr12_-_56727676 0.15 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr3_-_19975665 0.15 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chr2_+_223725652 0.14 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr15_+_63414760 0.14 ENST00000557972.1
LACTB
lactamase, beta
chr3_-_10362725 0.14 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13
SEC13 homolog (S. cerevisiae)
chr3_+_138340067 0.14 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr12_-_118628350 0.13 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr5_+_175740083 0.12 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr3_+_99986036 0.12 ENST00000471098.1
TBC1D23
TBC1 domain family, member 23
chr11_-_36619771 0.10 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr22_-_43411106 0.10 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr4_+_108815402 0.10 ENST00000503385.1
SGMS2
sphingomyelin synthase 2
chr15_+_63413990 0.09 ENST00000261893.4
LACTB
lactamase, beta
chr16_-_31076332 0.08 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr3_+_111393501 0.05 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr16_-_31076273 0.05 ENST00000426488.2
ZNF668
zinc finger protein 668
chr8_+_86999516 0.04 ENST00000521564.1
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr12_-_56321397 0.04 ENST00000557259.1
ENST00000549939.1
WIBG
within bgcn homolog (Drosophila)
chr17_-_48207115 0.04 ENST00000511964.1
SAMD14
sterile alpha motif domain containing 14
chrX_-_72097698 0.03 ENST00000373530.1
DMRTC1
DMRT-like family C1
chr21_+_18811205 0.03 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr2_-_27486951 0.03 ENST00000432351.1
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr12_-_56727487 0.03 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr4_+_619386 0.03 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr1_+_12851545 0.02 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr2_-_70780572 0.02 ENST00000450929.1
TGFA
transforming growth factor, alpha
chrX_+_72062802 0.02 ENST00000373533.1
DMRTC1B
DMRT-like family C1B
chr10_+_86004802 0.01 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
RGR
retinal G protein coupled receptor
chr4_+_619347 0.01 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr3_-_149293990 0.01 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr4_-_170679024 0.01 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.4 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.1 0.4 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 1.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.3 GO:0030035 microspike assembly(GO:0030035) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.7 GO:0061162 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.3 GO:0008272 sulfate transport(GO:0008272)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.6 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 1.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.4 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac