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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for DLX3_EVX1_MEOX1
Z-value: 1.14
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Transcription factors associated with DLX3_EVX1_MEOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EVX1 | hg19_v2_chr7_+_27282319_27282394 | 0.29 | 7.1e-01 | Click! |
| DLX3 | hg19_v2_chr17_-_48072574_48072597 | 0.20 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_66536248 Show fit | 2.06 |
ENST00000514260.1
ENST00000507117.1 |
RP11-807H7.1 |
|
| chr16_+_53133070 Show fit | 1.73 |
ENST00000565832.1
|
chromodomain helicase DNA binding protein 9 |
|
| chr7_-_99716914 Show fit | 1.31 |
ENST00000431404.2
|
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa |
|
| chr15_-_37393406 Show fit | 1.00 |
ENST00000338564.5
ENST00000558313.1 ENST00000340545.5 |
Meis homeobox 2 |
|
| chr18_-_33709268 Show fit | 0.95 |
ENST00000269187.5
ENST00000590986.1 ENST00000440549.2 |
solute carrier family 39 (zinc transporter), member 6 |
|
| chr17_-_57229155 Show fit | 0.94 |
ENST00000584089.1
|
spindle and kinetochore associated complex subunit 2 |
|
| chr12_+_28410128 Show fit | 0.93 |
ENST00000381259.1
ENST00000381256.1 |
coiled-coil domain containing 91 |
|
| chr5_+_31193847 Show fit | 0.70 |
ENST00000514738.1
ENST00000265071.2 |
cadherin 6, type 2, K-cadherin (fetal kidney) |
|
| chrM_+_8366 Show fit | 0.66 |
ENST00000361851.1
|
mitochondrially encoded ATP synthase 8 |
|
| chr1_-_68698197 Show fit | 0.66 |
ENST00000370973.2
ENST00000370971.1 |
wntless Wnt ligand secretion mediator |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX3_EVX1_MEOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 1.0 | GO:0008542 | visual learning(GO:0008542) |
| 0.2 | 0.9 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.1 | 0.9 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.9 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 0.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 0.6 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 0.5 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.5 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 0.4 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.4 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.4 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 0.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.0 | 0.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.4 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 0.4 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.1 | 0.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.4 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.4 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.6 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.4 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.3 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |