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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for DDIT3
Z-value: 1.29
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Transcription factors associated with DDIT3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DDIT3 | hg19_v2_chr12_-_57914275_57914304 | 0.84 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_186330712 Show fit | 2.52 |
ENST00000411641.2
ENST00000273784.5 |
alpha-2-HS-glycoprotein |
|
| chr3_-_148939598 Show fit | 1.86 |
ENST00000455472.3
|
ceruloplasmin (ferroxidase) |
|
| chr1_+_150954493 Show fit | 1.74 |
ENST00000368947.4
|
annexin A9 |
|
| chr6_-_86353510 Show fit | 1.28 |
ENST00000444272.1
|
synaptotagmin binding, cytoplasmic RNA interacting protein |
|
| chr11_-_8739383 Show fit | 1.01 |
ENST00000531060.1
|
suppression of tumorigenicity 5 |
|
| chr11_+_47279155 Show fit | 0.92 |
ENST00000444396.1
ENST00000457932.1 ENST00000412937.1 |
nuclear receptor subfamily 1, group H, member 3 |
|
| chr10_-_92681033 Show fit | 0.79 |
ENST00000371697.3
|
ankyrin repeat domain 1 (cardiac muscle) |
|
| chr12_-_12491608 Show fit | 0.74 |
ENST00000545735.1
|
MANSC domain containing 1 |
|
| chr3_+_38017264 Show fit | 0.73 |
ENST00000436654.1
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr3_-_148939835 Show fit | 0.70 |
ENST00000264613.6
|
ceruloplasmin (ferroxidase) |
Network of associatons between targets according to the STRING database.
First level regulatory network of DDIT3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 2.5 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.4 | 1.8 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.1 | 1.3 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.2 | 1.2 | GO:0097112 | gamma-aminobutyric acid receptor clustering(GO:0097112) |
| 0.1 | 1.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.9 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.2 | 0.7 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.2 | 0.6 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 1.3 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.4 | 1.2 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.1 | 1.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.9 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.6 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.5 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.0 | 0.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.5 | GO:0044447 | axoneme part(GO:0044447) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 1.8 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.0 | 1.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.8 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 1.7 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.0 | 1.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.3 | 1.2 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.3 | 0.8 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.0 | 0.7 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.2 | 0.6 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.5 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.5 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |