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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for CREB5_CREM_JUNB
Z-value: 1.86
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Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000146592.12 | cAMP responsive element binding protein 5 | |
| ENSG00000095794.15 | cAMP responsive element modulator | |
| ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg19_v2_chr10_+_35416223_35416405 | 0.94 | 6.0e-02 | Click! |
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.77 | 2.3e-01 | Click! |
| CREB5 | hg19_v2_chr7_+_28448995_28449011 | 0.46 | 5.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.3 | 3.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 2.7 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 2.6 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.6 | 2.5 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 2.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.3 | 2.1 | GO:1902741 | interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
| 0.1 | 2.1 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 2.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.2 | 1.7 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.2 | 3.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 2.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 2.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 2.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 2.1 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 1.8 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.1 | 1.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.4 | 1.6 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.1 | 1.6 | GO:0072546 | ER membrane protein complex(GO:0072546) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 3.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 2.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 2.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 2.2 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.2 | 2.1 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.0 | 1.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.8 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 1.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.9 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 2.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.6 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 1.6 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |