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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for CEBPG
Z-value: 1.45
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Transcription factors associated with CEBPG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPG | hg19_v2_chr19_+_33865218_33865254 | -0.89 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102668879 Show fit | 2.96 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr19_+_39786962 Show fit | 2.93 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr1_+_158979680 Show fit | 1.78 |
ENST00000368131.4
ENST00000340979.6 |
interferon, gamma-inducible protein 16 |
|
| chr11_-_33913708 Show fit | 1.74 |
ENST00000257818.2
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr2_-_191885686 Show fit | 1.73 |
ENST00000432058.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr1_+_158979686 Show fit | 1.72 |
ENST00000368132.3
ENST00000295809.7 |
interferon, gamma-inducible protein 16 |
|
| chr1_+_158979792 Show fit | 1.71 |
ENST00000359709.3
ENST00000430894.2 |
interferon, gamma-inducible protein 16 |
|
| chr19_-_1155118 Show fit | 1.69 |
ENST00000590998.1
|
strawberry notch homolog 2 (Drosophila) |
|
| chr7_+_22766766 Show fit | 1.67 |
ENST00000426291.1
ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1 |
interleukin 6 (interferon, beta 2) |
|
| chr6_+_31895480 Show fit | 1.45 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0032732 | positive regulation of interleukin-1 production(GO:0032732) |
| 0.1 | 3.2 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.7 | 2.9 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.2 | 2.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 2.4 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 0.6 | 1.7 | GO:2000366 | regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 0.4 | 1.7 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.4 | 1.7 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
| 0.1 | 1.7 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.4 | 1.4 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.4 | 2.8 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.1 | 2.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 1.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 0.5 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.3 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 0.2 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 5.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 5.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 3.0 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 3.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.8 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 1.7 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 1.6 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.4 | 1.2 | GO:0070996 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996) |
| 0.2 | 1.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 1.7 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.9 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 1.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.5 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |