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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for BATF
Z-value: 3.24
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Transcription factors associated with BATF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BATF | hg19_v2_chr14_+_75988768_75988826 | 0.62 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_91087651 Show fit | 5.84 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr7_-_92777606 Show fit | 3.88 |
ENST00000437805.1
ENST00000446959.1 ENST00000439952.1 ENST00000414791.1 ENST00000446033.1 ENST00000411955.1 ENST00000318238.4 |
sterile alpha motif domain containing 9-like |
|
| chr10_+_91061712 Show fit | 3.28 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr21_+_42798094 Show fit | 3.13 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr11_-_102668879 Show fit | 2.99 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr1_+_158979686 Show fit | 2.85 |
ENST00000368132.3
ENST00000295809.7 |
interferon, gamma-inducible protein 16 |
|
| chr17_+_58018269 Show fit | 2.70 |
ENST00000591035.1
|
Uncharacterized protein |
|
| chr10_+_91092241 Show fit | 2.70 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr1_+_158979792 Show fit | 2.67 |
ENST00000359709.3
ENST00000430894.2 |
interferon, gamma-inducible protein 16 |
|
| chr19_+_39759154 Show fit | 2.63 |
ENST00000331982.5
|
interferon, lambda 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BATF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.2 | 8.5 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 0.2 | 7.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 6.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.1 | 5.3 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.9 | 4.4 | GO:1990169 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.9 | 4.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 3.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 3.5 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.2 | 3.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 5.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 4.1 | GO:0031430 | M band(GO:0031430) |
| 0.4 | 3.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 3.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 3.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 2.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 2.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 2.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 4.9 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.1 | 4.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 1.5 | 4.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.3 | 3.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 3.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 2.9 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.4 | 2.5 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.4 | 2.5 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.2 | 2.5 | GO:0038132 | neuregulin binding(GO:0038132) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 7.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 5.5 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 3.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.2 | 3.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 3.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.1 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 8.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 4.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 3.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 3.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 2.6 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 2.5 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 2.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |