ISMARA results: BACH1_NFE2

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for BACH1_NFE2_NFE2L2

Z-value: 1.79

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Transcription factors associated with BACH1_NFE2_NFE2L2

Gene Symbol	Gene ID	Gene Info
BACH1 Ensembl NCBI GeneCards UniProt	ENSG00000156273.11	BTB domain and CNC homolog 1
NFE2 Ensembl NCBI GeneCards UniProt	ENSG00000123405.9	nuclear factor, erythroid 2
NFE2L2 Ensembl NCBI GeneCards UniProt	ENSG00000116044.11	nuclear factor, erythroid 2 like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFE2	hg19_v2_chr12_-_54694758_54694805	-0.70	3.0e-01	Click!
NFE2L2	hg19_v2_chr2_-_178129551_178129572	-0.65	3.5e-01	Click!
BACH1	hg19_v2_chr21_+_30673091_30673135	0.62	3.8e-01	Click!

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_116840728 Show fit	2.32	ENST00000265132.3	AMBP Ensembl NCBI GeneCards UniProt Show fit	alpha-1-microglobulin/bikunin precursor
chr4_-_987164 Show fit	1.24	ENST00000398520.2	SLC26A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 26 (anion exchanger), member 1
chr20_+_48909240 Show fit	1.15	ENST00000371639.3	RP11-290F20.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-290F20.1
chr11_+_67351213 Show fit	1.07	ENST00000398603.1	GSTP1 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase pi 1
chr11_+_67351019 Show fit	1.06	ENST00000398606.3	GSTP1 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase pi 1
chr2_-_220117867 Show fit	1.03	ENST00000456818.1 ENST00000447205.1	TUBA4A Ensembl NCBI GeneCards UniProt Show fit	tubulin, alpha 4a
chr11_-_2924720 Show fit	1.03	ENST00000455942.2	SLC22A18AS Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22 (organic cation transporter), member 18 antisense
chr22_+_45072925 Show fit	1.01	ENST00000006251.7	PRR5 Ensembl NCBI GeneCards UniProt Show fit	proline rich 5 (renal)
chr19_+_49467232 Show fit	0.98	ENST00000599784.1 ENST00000594305.1	CTD-2639E6.9 Ensembl NCBI GeneCards UniProt Show fit	CTD-2639E6.9
chr18_-_55253989 Show fit	0.97	ENST00000262093.5	FECH Ensembl NCBI GeneCards UniProt Show fit	ferrochelatase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.5	GO:0070541	response to platinum ion(GO:0070541)
0.2	2.2	GO:0018298	protein-chromophore linkage(GO:0018298)
0.5	2.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	2.1	GO:0043276	anoikis(GO:0043276)
0.2	1.8	GO:0050428	purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.1	1.8	GO:0038203	TORC2 signaling(GO:0038203)
0.1	1.3	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.1	1.2	GO:0002191	cap-dependent translational initiation(GO:0002191)
0.1	1.2	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1	1.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)

Showing 1 to 10 of 111 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0072562	blood microparticle(GO:0072562)
0.7	2.1	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.1	2.0	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	1.8	GO:0031932	TORC2 complex(GO:0031932)
0.0	1.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	1.1	GO:0097512	cardiac myofibril(GO:0097512)
0.0	1.0	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1	0.9	GO:0072687	meiotic spindle(GO:0072687)
0.0	0.9	GO:0000812	Swr1 complex(GO:0000812)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.5	GO:0004325	ferrochelatase activity(GO:0004325)
0.8	2.3	GO:0019862	IgA binding(GO:0019862)
0.4	2.1	GO:0070026	nitric oxide binding(GO:0070026)
0.4	2.0	GO:1990450	linear polyubiquitin binding(GO:1990450)
0.1	1.8	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	1.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	1.4	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	1.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.3	0.9	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.2	0.9	GO:0016005	phospholipase A2 activator activity(GO:0016005)

Showing 1 to 10 of 85 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
2.0	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
2.0	PID MTOR 4PATHWAY	mTOR signaling pathway
2.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
1.5	PID E2F PATHWAY	E2F transcription factor network
1.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	2.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	2.0	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	1.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	1.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	1.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.9	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	0.8	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.8	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)

Showing 1 to 10 of 23 entries

Results for BACH1_NFE2_NFE2L2

Z-value: 1.79

Motif logo

Transcription factors associated with BACH1_NFE2_NFE2L2

Activity-expression correlation:

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: