ISMARA results: ATF6

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ATF6

Z-value: 1.18

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Transcription factors associated with ATF6

Gene Symbol	Gene ID	Gene Info
ATF6 Ensembl NCBI GeneCards UniProt	ENSG00000118217.5	activating transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF6	hg19_v2_chr1_+_161736072_161736093	-0.51	4.9e-01	Click!

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_20850171 Show fit	1.00	ENST00000445987.1	MED15 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 15
chr21_-_38445297 Show fit	0.89	ENST00000430792.1 ENST00000399103.1	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_6522922 Show fit	0.88	ENST00000601673.1	FLJ20306 Ensembl NCBI GeneCards UniProt Show fit	CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein
chr9_+_111696664 Show fit	0.82	ENST00000374624.3 ENST00000445175.1	FAM206A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 206, member A
chr12_+_147052 Show fit	0.79	ENST00000594563.1	AC026369.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr3_+_184530173 Show fit	0.78	ENST00000453056.1	VPS8 Ensembl NCBI GeneCards UniProt Show fit	vacuolar protein sorting 8 homolog (S. cerevisiae)
chr21_-_38445011 Show fit	0.72	ENST00000464265.1 ENST00000399102.1	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class P
chr16_+_2570431 Show fit	0.72	ENST00000563556.1	AMDHD2 Ensembl NCBI GeneCards UniProt Show fit	amidohydrolase domain containing 2
chr21_-_38445470 Show fit	0.70	ENST00000399098.1	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class P
chr13_+_36920569 Show fit	0.66	ENST00000379848.2	SPG20OS Ensembl NCBI GeneCards UniProt Show fit	SPG20 opposite strand

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.1	1.1	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.1	0.8	GO:0010734	protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1	0.8	GO:0090238	positive regulation of arachidonic acid secretion(GO:0090238)
0.1	0.8	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.7	GO:0002021	response to dietary excess(GO:0002021)
0.2	0.6	GO:2000176	regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1	0.6	GO:1990180	mitochondrial tRNA 3'-end processing(GO:1990180)
0.1	0.6	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.1	0.5	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)

Showing 1 to 10 of 84 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1	1.1	GO:0033263	CORVET complex(GO:0033263)
0.0	1.1	GO:0016592	mediator complex(GO:0016592)
0.1	0.8	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1	0.5	GO:0097452	GAIT complex(GO:0097452)
0.0	0.5	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	0.5	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.4	GO:0036038	MKS complex(GO:0036038)
0.0	0.4	GO:0030127	COPII vesicle coat(GO:0030127)

Showing 1 to 10 of 31 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	1.3	GO:0000049	tRNA binding(GO:0000049)
0.0	0.9	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	0.6	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.6	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.6	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.5	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.5	GO:0008143	poly(A) binding(GO:0008143)
0.1	0.4	GO:0015218	pyrimidine nucleotide transmembrane transporter activity(GO:0015218)

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.6	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins

Showing 1 to 9 of 9 entries

Results for ATF6

Z-value: 1.18

Motif logo

Transcription factors associated with ATF6

Activity-expression correlation:

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: