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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ATF4

Z-value: 0.30

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.772.3e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_41245160 0.55 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr15_+_89182178 0.26 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 0.26 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_-_133792480 0.22 ENST00000359237.4
PLAC1
placenta-specific 1
chr11_-_33913708 0.21 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_+_89181974 0.21 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr19_+_11350278 0.19 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr2_+_65663812 0.18 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr7_-_99006443 0.15 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr10_+_102106829 0.13 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_149832704 0.13 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
HIST2H4B
histone cluster 2, H4b
chr3_+_11314099 0.12 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr12_+_93963590 0.12 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr7_+_99006550 0.12 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr7_-_48068699 0.12 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr7_-_48068671 0.11 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr11_+_58938903 0.11 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr1_-_44497118 0.11 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_178840157 0.10 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr5_+_143584814 0.10 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr16_-_67694597 0.10 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr11_-_3078616 0.09 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr11_+_93754513 0.09 ENST00000315765.9
HEPHL1
hephaestin-like 1
chr6_+_126102292 0.09 ENST00000368357.3
NCOA7
nuclear receptor coactivator 7
chr7_+_99006232 0.08 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chrX_-_71792477 0.08 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr5_+_167956121 0.08 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr6_+_151187074 0.08 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr11_-_3078838 0.07 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr12_+_64798826 0.07 ENST00000540203.1
XPOT
exportin, tRNA
chr3_-_99595037 0.07 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chrX_+_77359726 0.07 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chr1_+_154244987 0.06 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr1_+_241815577 0.06 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr1_-_44497024 0.06 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_-_23762777 0.06 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr9_-_34665983 0.06 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
RP11-195F19.5
HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015
chr1_+_149804218 0.06 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr14_-_88282595 0.06 ENST00000554519.1
RP11-1152H15.1
RP11-1152H15.1
chr3_-_99594948 0.06 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr11_+_118955583 0.06 ENST00000278715.3
ENST00000536813.1
ENST00000537841.1
ENST00000542729.1
ENST00000546302.1
ENST00000442944.2
ENST00000544387.1
ENST00000543090.1
HMBS
hydroxymethylbilane synthase
chr5_+_174151536 0.06 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr12_-_25101920 0.06 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_-_29457832 0.06 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr3_-_48130707 0.06 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr17_-_77967433 0.05 ENST00000571872.1
TBC1D16
TBC1 domain family, member 16
chr1_+_162351503 0.05 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chrX_+_77359671 0.05 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chr17_+_73089382 0.05 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr1_+_239882842 0.05 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr7_-_50860565 0.05 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr12_+_57914742 0.05 ENST00000551351.1
MBD6
methyl-CpG binding domain protein 6
chr12_-_25102252 0.05 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr8_-_116681686 0.05 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr1_+_112016414 0.05 ENST00000343534.5
ENST00000369718.3
C1orf162
chromosome 1 open reading frame 162
chr8_-_38008783 0.04 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr12_+_56862301 0.04 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr17_-_77813186 0.04 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4
chr1_+_52521928 0.04 ENST00000489308.2
BTF3L4
basic transcription factor 3-like 4
chr11_+_62649158 0.04 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr12_+_106994905 0.04 ENST00000357881.4
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chrX_-_15332665 0.04 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr11_-_128737163 0.04 ENST00000324003.3
ENST00000392665.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr4_-_70725856 0.04 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr16_-_70323422 0.04 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr5_+_154135029 0.04 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr19_-_51014460 0.04 ENST00000595669.1
JOSD2
Josephin domain containing 2
chr12_+_57623907 0.04 ENST00000553529.1
ENST00000554310.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_+_30634297 0.04 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr14_+_75894714 0.04 ENST00000559060.1
JDP2
Jun dimerization protein 2
chr10_+_50507232 0.04 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr7_-_93633684 0.03 ENST00000222547.3
ENST00000425626.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr7_-_115670792 0.03 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr3_+_11314072 0.03 ENST00000444619.1
ATG7
autophagy related 7
chr17_-_76836729 0.03 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
USP36
ubiquitin specific peptidase 36
chr15_+_40886439 0.03 ENST00000532056.1
ENST00000399668.2
CASC5
cancer susceptibility candidate 5
chr1_-_216978709 0.03 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr8_-_116680833 0.03 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr11_-_128737259 0.03 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr17_-_76836963 0.03 ENST00000312010.6
USP36
ubiquitin specific peptidase 36
chr19_-_51014588 0.03 ENST00000598418.1
JOSD2
Josephin domain containing 2
chr7_-_115670804 0.02 ENST00000320239.7
TFEC
transcription factor EC
chr22_-_43485381 0.02 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr22_+_50919944 0.02 ENST00000395738.2
ADM2
adrenomedullin 2
chr12_+_57914481 0.02 ENST00000548887.1
MBD6
methyl-CpG binding domain protein 6
chr3_-_48130314 0.02 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr22_+_42229100 0.02 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr7_-_138386097 0.02 ENST00000421622.1
SVOPL
SVOP-like
chrX_+_48398053 0.02 ENST00000537536.1
ENST00000418627.1
TBC1D25
TBC1 domain family, member 25
chr17_-_79895097 0.02 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr12_+_57623869 0.02 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_+_162602244 0.02 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr19_-_51014345 0.02 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr1_-_167883353 0.02 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr17_-_79895154 0.02 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chr7_-_48068643 0.02 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr19_-_49258606 0.02 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr2_-_98280383 0.02 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chrX_-_68385354 0.02 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr4_-_153457197 0.02 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr9_+_36169380 0.02 ENST00000335119.2
CCIN
calicin
chr19_-_51192661 0.02 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr15_+_40886199 0.01 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
CASC5
cancer susceptibility candidate 5
chr14_+_24563510 0.01 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr12_+_57624059 0.01 ENST00000557427.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr22_+_50919995 0.01 ENST00000362068.2
ENST00000395737.1
ADM2
adrenomedullin 2
chr21_-_44495964 0.01 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr3_-_33686743 0.01 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chrX_-_68385274 0.01 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr12_-_10324716 0.01 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr3_-_33686925 0.01 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr2_+_7118755 0.01 ENST00000433456.1
RNF144A
ring finger protein 144A
chr12_+_6493406 0.01 ENST00000543190.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr12_+_57624119 0.01 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_+_48211048 0.01 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr12_+_57623477 0.01 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_50135588 0.01 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr12_+_57624085 0.00 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_+_228353495 0.00 ENST00000366711.3
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr5_+_33440802 0.00 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS
threonyl-tRNA synthetase

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.2 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.1 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.1 GO:0034727 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0033967 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795)
0.0 0.1 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.0 GO:0017143 insecticide metabolic process(GO:0017143) cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 0.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.0 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.1 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.1 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)