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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for AR_NR3C2

Z-value: 0.59

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_66764465-0.909.6e-02Click!
NR3C2hg19_v2_chr4_-_149363662_149363688-0.633.7e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56642041 1.55 ENST00000245185.5
MT2A
metallothionein 2A
chr16_+_56642489 1.26 ENST00000561491.1
MT2A
metallothionein 2A
chr16_+_56716336 0.83 ENST00000394485.4
ENST00000562939.1
MT1X
metallothionein 1X
chr11_+_18287801 0.61 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr1_-_1149506 0.59 ENST00000379236.3
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr11_+_18287721 0.54 ENST00000356524.4
SAA1
serum amyloid A1
chr19_-_42916499 0.44 ENST00000601189.1
ENST00000599211.1
LIPE
lipase, hormone-sensitive
chr13_+_114462193 0.35 ENST00000375353.3
TMEM255B
transmembrane protein 255B
chr9_-_106087316 0.33 ENST00000411575.1
RP11-341A22.2
RP11-341A22.2
chr7_-_75241096 0.33 ENST00000420909.1
HIP1
huntingtin interacting protein 1
chr1_+_1846519 0.31 ENST00000378604.3
CALML6
calmodulin-like 6
chr8_-_49833978 0.30 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr20_+_45947246 0.28 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr22_+_18632666 0.25 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr14_-_24616426 0.25 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr19_+_35630926 0.23 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35741466 0.23 ENST00000599658.1
LSR
lipolysis stimulated lipoprotein receptor
chr8_-_49834299 0.21 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr6_+_127898312 0.21 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr15_+_31658349 0.19 ENST00000558844.1
KLF13
Kruppel-like factor 13
chr8_-_72756667 0.19 ENST00000325509.4
MSC
musculin
chr19_+_35630628 0.18 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr14_+_24616588 0.16 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr1_-_145715565 0.15 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160
CD160 molecule
chr8_-_21669826 0.15 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr19_+_57874835 0.15 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr4_-_185395191 0.14 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr11_-_114271139 0.14 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr11_+_48002076 0.13 ENST00000418331.2
ENST00000440289.2
PTPRJ
protein tyrosine phosphatase, receptor type, J
chr8_-_145634666 0.13 ENST00000531042.1
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr4_-_69817481 0.12 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr6_+_123317116 0.12 ENST00000275162.5
CLVS2
clavesin 2
chr10_+_26932068 0.12 ENST00000544033.1
ENST00000454991.1
LINC00202-2
RP13-16H11.7
long intergenic non-protein coding RNA 202-2
RP13-16H11.7
chr4_-_135122903 0.12 ENST00000421491.3
ENST00000529122.2
PABPC4L
poly(A) binding protein, cytoplasmic 4-like
chr12_+_122241928 0.11 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chr2_-_75788424 0.11 ENST00000410071.1
EVA1A
eva-1 homolog A (C. elegans)
chr4_+_75311019 0.11 ENST00000502307.1
AREG
amphiregulin
chr19_+_35630344 0.10 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr14_-_106845789 0.10 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr11_-_5959840 0.10 ENST00000412903.1
TRIM5
tripartite motif containing 5
chr1_+_93811438 0.10 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr11_+_65851443 0.09 ENST00000533756.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr9_+_131683174 0.09 ENST00000372592.3
ENST00000428610.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr12_-_106480587 0.09 ENST00000548902.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_-_4852915 0.09 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr2_+_238395879 0.09 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr19_+_1261106 0.09 ENST00000588411.1
CIRBP
cold inducible RNA binding protein
chr12_+_66582919 0.09 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr1_-_204119009 0.08 ENST00000444817.1
ETNK2
ethanolamine kinase 2
chr2_+_238395803 0.08 ENST00000264605.3
MLPH
melanophilin
chr11_+_103907308 0.08 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr4_+_75310851 0.08 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr3_-_119396193 0.08 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17
COX17 cytochrome c oxidase copper chaperone
chr12_+_1099675 0.08 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr5_+_140186647 0.08 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr1_-_10856694 0.07 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr14_-_106866934 0.07 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chrX_-_117119243 0.07 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr19_-_3786354 0.07 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr1_-_49242553 0.07 ENST00000371833.3
BEND5
BEN domain containing 5
chr14_-_23623577 0.07 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr10_-_375422 0.07 ENST00000434695.2
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr22_+_19939026 0.07 ENST00000406520.3
COMT
catechol-O-methyltransferase
chr18_-_48346415 0.06 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr12_-_10251603 0.06 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr16_-_25269134 0.06 ENST00000328086.7
ZKSCAN2
zinc finger with KRAB and SCAN domains 2
chr1_+_76262552 0.06 ENST00000263187.3
MSH4
mutS homolog 4
chr19_-_3786253 0.06 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr7_+_150147711 0.06 ENST00000307271.3
GIMAP8
GTPase, IMAP family member 8
chrX_-_80377162 0.06 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr4_-_8442438 0.06 ENST00000356406.5
ENST00000413009.2
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr17_-_19290117 0.06 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr2_-_231825668 0.06 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr19_+_8117636 0.06 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr2_+_27435179 0.06 ENST00000606999.1
ENST00000405489.3
ATRAID
all-trans retinoic acid-induced differentiation factor
chr2_+_242577097 0.05 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
ATG4B
autophagy related 4B, cysteine peptidase
chr8_-_145634731 0.05 ENST00000349769.3
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr2_+_242577027 0.05 ENST00000402096.1
ENST00000404914.3
ATG4B
autophagy related 4B, cysteine peptidase
chr4_+_75480629 0.05 ENST00000380846.3
AREGB
amphiregulin B
chr19_-_14117074 0.05 ENST00000588885.1
ENST00000254325.4
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr11_-_75380165 0.05 ENST00000304771.3
MAP6
microtubule-associated protein 6
chrX_+_2609207 0.04 ENST00000381192.3
CD99
CD99 molecule
chr14_-_106692191 0.04 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr1_-_24469602 0.04 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr17_+_38498594 0.04 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chr19_-_8408139 0.04 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr4_-_69215699 0.04 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr1_-_209979465 0.04 ENST00000542854.1
IRF6
interferon regulatory factor 6
chr8_+_91013577 0.04 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr16_-_787728 0.04 ENST00000567403.1
ENST00000562421.1
NARFL
nuclear prelamin A recognition factor-like
chr6_-_131299929 0.03 ENST00000531356.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr14_-_106668095 0.03 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr18_+_47087055 0.03 ENST00000577628.1
LIPG
lipase, endothelial
chr2_+_27435734 0.03 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr12_+_51318513 0.03 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr3_-_58563094 0.03 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr19_+_8117881 0.03 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr3_+_118864991 0.03 ENST00000295622.1
C3orf30
chromosome 3 open reading frame 30
chrX_+_2609317 0.03 ENST00000381187.3
ENST00000381184.1
CD99
CD99 molecule
chr2_-_242576864 0.02 ENST00000407315.1
THAP4
THAP domain containing 4
chr17_+_79031415 0.02 ENST00000572073.1
ENST00000573677.1
BAIAP2
BAI1-associated protein 2
chr3_-_98235962 0.02 ENST00000513873.1
CLDND1
claudin domain containing 1
chr1_-_27693349 0.02 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr11_-_506739 0.02 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr16_-_66584059 0.02 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr3_+_118865028 0.02 ENST00000460150.1
C3orf30
chromosome 3 open reading frame 30
chr22_+_38054721 0.02 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr15_-_28344439 0.02 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II
chr14_-_106552755 0.02 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chrX_+_2609356 0.02 ENST00000381180.3
ENST00000449611.1
CD99
CD99 molecule
chr7_-_4877677 0.02 ENST00000538469.1
RADIL
Ras association and DIL domains
chr19_+_58570605 0.01 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
ZNF135
zinc finger protein 135
chr8_-_110615669 0.01 ENST00000533394.1
SYBU
syntabulin (syntaxin-interacting)
chr17_+_38333263 0.01 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr19_-_45657028 0.01 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr19_+_54704610 0.01 ENST00000302907.4
RPS9
ribosomal protein S9
chr17_-_16472483 0.01 ENST00000395824.1
ENST00000448349.2
ENST00000395825.3
ZNF287
zinc finger protein 287
chr12_+_56615761 0.01 ENST00000447747.1
ENST00000399713.2
NABP2
nucleic acid binding protein 2
chr16_+_67207872 0.01 ENST00000563258.1
ENST00000568146.1
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr16_+_67207838 0.00 ENST00000566871.1
ENST00000268605.7
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr11_-_236326 0.00 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr8_+_9046503 0.00 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr11_+_236540 0.00 ENST00000532097.1
PSMD13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr2_-_109605663 0.00 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.8 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.1 0.3 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.1 0.4 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.5 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.2 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.2 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.6 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 1.2 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.0 0.2 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0050666 cellular response to phosphate starvation(GO:0016036) regulation of sulfur amino acid metabolic process(GO:0031335) positive regulation of sulfur amino acid metabolic process(GO:0031337) regulation of homocysteine metabolic process(GO:0050666) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.0 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0005713 recombination nodule(GO:0005713)
0.0 0.1 GO:1990462 omegasome(GO:1990462)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.4 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 1.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.8 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 3.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis