ISMARA results: ZNF652

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ZNF652

Z-value: 1.25

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Transcription factors associated with ZNF652

Gene Symbol	Gene ID	Gene Info
ZNF652 Ensembl NCBI GeneCards UniProt	ENSG00000198740.4	zinc finger protein 652

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF652	hg19_v2_chr17_-_47439437_47439533	-0.62	3.8e-01	Click!

Activity profile of ZNF652 motif

Sorted Z-values of ZNF652 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_6982442 Show fit	1.22	ENST00000523102.1 ENST00000524270.1 ENST00000519357.1	SPSB2 Ensembl NCBI GeneCards UniProt Show fit	splA/ryanodine receptor domain and SOCS box containing 2
chr16_+_3068393 Show fit	0.80	ENST00000573001.1	TNFRSF12A Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor receptor superfamily, member 12A
chr5_+_149865838 Show fit	0.79	ENST00000519157.1	NDST1 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr11_-_118966167 Show fit	0.73	ENST00000530167.1	H2AFX Ensembl NCBI GeneCards UniProt Show fit	H2A histone family, member X
chr1_-_6662919 Show fit	0.68	ENST00000377658.4 ENST00000377663.3	KLHL21 Ensembl NCBI GeneCards UniProt Show fit	kelch-like family member 21
chr10_+_104263743 Show fit	0.66	ENST00000369902.3 ENST00000369899.2 ENST00000423559.2	SUFU Ensembl NCBI GeneCards UniProt Show fit	suppressor of fused homolog (Drosophila)
chr12_-_49463753 Show fit	0.65	ENST00000301068.6	RHEBL1 Ensembl NCBI GeneCards UniProt Show fit	Ras homolog enriched in brain like 1
chr1_+_155036204 Show fit	0.63	ENST00000368409.3 ENST00000359751.4 ENST00000427683.2 ENST00000556931.1 ENST00000505139.1	EFNA4 Ensembl NCBI GeneCards UniProt Show fit EFNA3 Ensembl NCBI GeneCards UniProt Show fit EFNA3 Ensembl NCBI GeneCards UniProt Show fit	ephrin-A4 ephrin-A3 Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3
chr14_-_21562648 Show fit	0.62	ENST00000555270.1	ZNF219 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 219
chr4_-_90756769 Show fit	0.60	ENST00000345009.4 ENST00000505199.1 ENST00000502987.1	SNCA Ensembl NCBI GeneCards UniProt Show fit	synuclein, alpha (non A4 component of amyloid precursor)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF652

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.7	GO:0097403	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1	1.6	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1	1.3	GO:0006477	protein sulfation(GO:0006477)
0.2	0.9	GO:1903285	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.2	0.9	GO:0046092	deoxycytidine metabolic process(GO:0046092)
0.3	0.8	GO:0061580	colon epithelial cell migration(GO:0061580)
0.1	0.8	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.8	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1	0.8	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.8	GO:0071480	cellular response to gamma radiation(GO:0071480)

Showing 1 to 10 of 65 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.9	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.7	GO:0043260	laminin-11 complex(GO:0043260)
0.1	0.7	GO:0005827	polar microtubule(GO:0005827)
0.0	0.7	GO:0001673	male germ cell nucleus(GO:0001673)
0.0	0.7	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.5	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.4	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.4	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.3	GO:0070765	gamma-secretase complex(GO:0070765)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2	1.3	GO:0050119	N-acetylglucosamine deacetylase activity(GO:0050119)
0.1	1.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	1.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2	0.9	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	0.9	GO:0004137	deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.2	0.8	GO:0003943	N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1	0.8	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.8	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1	0.5	GO:0043120	tumor necrosis factor binding(GO:0043120)

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.0	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.9	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	PID EPHA FWDPATHWAY	EPHA forward signaling
0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.8	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	1.7	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	1.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	1.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.9	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis

Showing 1 to 10 of 10 entries

Results for ZNF652

Z-value: 1.25

Motif logo

Transcription factors associated with ZNF652

Activity-expression correlation:

Activity profile of ZNF652 motif

Sorted Z-values of ZNF652 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF652

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: