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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ZNF524
Z-value: 3.10
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Transcription factors associated with ZNF524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF524 | hg19_v2_chr19_+_56111680_56111735 | 0.95 | 4.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.5 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.9 | 4.6 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.4 | 3.6 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 1.2 | 3.5 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.5 | 3.1 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.1 | 2.9 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.3 | 2.7 | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining(GO:2001033) |
| 0.4 | 2.5 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 2.5 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 2.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 3.8 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.2 | 3.6 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 3.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 2.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 2.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 2.1 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.4 | 2.0 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 1.8 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 1.7 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 10.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 6.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.2 | 3.5 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.9 | 3.4 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.0 | 2.8 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.7 | GO:0050072 | m7G(5')pppN diphosphatase activity(GO:0050072) |
| 0.4 | 2.5 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 2.2 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 2.1 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.4 | 2.0 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 4.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.3 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 2.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 1.7 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 2.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.4 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 2.2 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 2.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 2.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 1.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |