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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ZKSCAN3

Z-value: 0.97

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.257.5e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39786962 2.97 ENST00000333625.2
IFNL1
interferon, lambda 1
chr19_-_39735646 1.17 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_+_39759154 0.78 ENST00000331982.5
IFNL2
interferon, lambda 2
chr22_+_50312379 0.48 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr15_+_41624892 0.40 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr22_+_50312316 0.38 ENST00000328268.4
CRELD2
cysteine-rich with EGF-like domains 2
chr11_-_64013288 0.30 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_191745560 0.29 ENST00000338435.4
GLS
glutaminase
chr5_-_65017921 0.21 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr1_-_19811132 0.21 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr22_+_50312274 0.21 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2
chr17_-_62499334 0.20 ENST00000579996.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr19_-_49258606 0.20 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr7_+_155089486 0.18 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr15_+_74610894 0.17 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr2_-_175351744 0.17 ENST00000295500.4
ENST00000392552.2
ENST00000392551.2
GPR155
G protein-coupled receptor 155
chr1_+_66258846 0.16 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_180235755 0.16 ENST00000502678.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_-_31508304 0.15 ENST00000376177.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr18_-_74728998 0.15 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr1_+_226250379 0.15 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr5_+_65018017 0.15 ENST00000380985.5
ENST00000502464.1
NLN
neurolysin (metallopeptidase M3 family)
chr7_+_155090271 0.13 ENST00000476756.1
INSIG1
insulin induced gene 1
chr14_+_94492674 0.13 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr1_+_3598871 0.13 ENST00000603362.1
ENST00000604479.1
TP73
tumor protein p73
chr7_-_37382683 0.13 ENST00000455879.1
ELMO1
engulfment and cell motility 1
chr1_-_115259337 0.13 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr10_+_21823079 0.12 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chrX_+_23352133 0.12 ENST00000379361.4
PTCHD1
patched domain containing 1
chr9_+_127023704 0.11 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr1_-_19811996 0.11 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr19_+_32836499 0.11 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr3_-_122512619 0.11 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr2_-_61244550 0.10 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr10_+_21823243 0.10 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr2_+_191745535 0.09 ENST00000320717.3
GLS
glutaminase
chr13_-_111567353 0.09 ENST00000310847.4
ENST00000267339.2
ENST00000375758.5
ANKRD10
ankyrin repeat domain 10
chr11_-_64013663 0.08 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_113573495 0.07 ENST00000446861.3
RASAL1
RAS protein activator like 1 (GAP1 like)
chr6_-_35656712 0.06 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr5_-_95297534 0.06 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr21_+_39668831 0.06 ENST00000419868.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_86622421 0.05 ENST00000370571.2
COL24A1
collagen, type XXIV, alpha 1
chr1_-_28415075 0.04 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
EYA3
eyes absent homolog 3 (Drosophila)
chr10_+_123922941 0.04 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr12_-_3982511 0.03 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr5_+_140079919 0.03 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr21_+_39668478 0.02 ENST00000398927.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_109535373 0.02 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr5_-_114598548 0.02 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr17_-_60142609 0.02 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_61244308 0.02 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr17_+_36908984 0.02 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr1_+_93913665 0.01 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chrX_-_135338503 0.01 ENST00000370663.5
MAP7D3
MAP7 domain containing 3
chr6_+_32936353 0.01 ENST00000374825.4
BRD2
bromodomain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.3 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.1 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.8 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.2 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.0 4.9 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle