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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for YY1_YY2
Z-value: 1.66
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY2 | hg19_v2_chrX_+_21874105_21874105 | -0.84 | 1.6e-01 | Click! |
| YY1 | hg19_v2_chr14_+_100705322_100705360 | -0.81 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_30934376 Show fit | 3.55 |
ENST00000562798.1
ENST00000471231.2 |
F-box and leucine-rich repeat protein 19 |
|
| chr19_+_507299 Show fit | 2.43 |
ENST00000359315.5
|
tubulin polyglutamylase complex subunit 1 |
|
| chrX_-_153236819 Show fit | 1.73 |
ENST00000354233.3
|
host cell factor C1 (VP16-accessory protein) |
|
| chrX_+_153237740 Show fit | 1.57 |
ENST00000369982.4
|
transmembrane protein 187 |
|
| chr16_+_30662085 Show fit | 1.50 |
ENST00000569864.1
|
proline rich 14 |
|
| chrX_-_153237258 Show fit | 1.40 |
ENST00000310441.7
|
host cell factor C1 (VP16-accessory protein) |
|
| chr16_+_30662050 Show fit | 1.29 |
ENST00000568754.1
|
proline rich 14 |
|
| chr11_-_62476965 Show fit | 1.13 |
ENST00000405837.1
ENST00000531524.1 |
Berardinelli-Seip congenital lipodystrophy 2 (seipin) |
|
| chr3_-_48700310 Show fit | 1.10 |
ENST00000164024.4
ENST00000544264.1 |
cadherin, EGF LAG seven-pass G-type receptor 3 |
|
| chr14_-_23504087 Show fit | 1.09 |
ENST00000493471.2
ENST00000460922.2 |
proteasome (prosome, macropain) subunit, beta type, 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.1 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 4.0 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 2.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.6 | 2.4 | GO:0090301 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.2 | 2.2 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 1.9 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 1.7 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.1 | 1.6 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 1.4 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 1.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.9 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 4.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 4.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 4.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 3.0 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 1.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 1.6 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 1.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 1.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0046972 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 2.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 2.4 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 2.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 1.6 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 1.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 1.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 1.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 1.3 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.0 | 1.3 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 0.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.7 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 3.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 2.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.2 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.1 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |