ISMARA results: WT1_MTF1

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for WT1_MTF1_ZBTB7B

Z-value: 1.36

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Transcription factors associated with WT1_MTF1_ZBTB7B

Gene Symbol	Gene ID	Gene Info
WT1 Ensembl NCBI GeneCards UniProt	ENSG00000184937.8	WT1 transcription factor
MTF1 Ensembl NCBI GeneCards UniProt	ENSG00000188786.9	metal regulatory transcription factor 1
ZBTB7B Ensembl NCBI GeneCards UniProt	ENSG00000160685.9	zinc finger and BTB domain containing 7B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB7B	hg19_v2_chr1_+_154975258_154975330	-0.99	1.4e-02	Click!
WT1	hg19_v2_chr11_-_32452357_32452363	0.35	6.5e-01	Click!
MTF1	hg19_v2_chr1_-_38325256_38325292	0.05	9.5e-01	Click!

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_57466629 Show fit	1.91	ENST00000371081.1 ENST00000338783.6	GNAS Ensembl NCBI GeneCards UniProt Show fit	GNAS complex locus
chr19_-_48673465 Show fit	1.79	ENST00000598938.1	LIG1 Ensembl NCBI GeneCards UniProt Show fit	ligase I, DNA, ATP-dependent
chr9_+_128509663 Show fit	1.24	ENST00000373489.5 ENST00000373483.2	PBX3 Ensembl NCBI GeneCards UniProt Show fit	pre-B-cell leukemia homeobox 3
chr17_-_46690839 Show fit	1.20	ENST00000498634.2	HOXB8 Ensembl NCBI GeneCards UniProt Show fit	homeobox B8
chr2_+_112812778 Show fit	1.04	ENST00000283206.4	TMEM87B Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 87B
chr20_+_57466461 Show fit	1.02	ENST00000306090.10	GNAS Ensembl NCBI GeneCards UniProt Show fit	GNAS complex locus
chr2_+_10091815 Show fit	0.99	ENST00000324907.9	GRHL1 Ensembl NCBI GeneCards UniProt Show fit	grainyhead-like 1 (Drosophila)
chr1_+_6845578 Show fit	0.99	ENST00000467404.2 ENST00000439411.2	CAMTA1 Ensembl NCBI GeneCards UniProt Show fit	calmodulin binding transcription activator 1
chr21_+_44394742 Show fit	0.96	ENST00000432907.2	PKNOX1 Ensembl NCBI GeneCards UniProt Show fit	PBX/knotted 1 homeobox 1
chr9_+_91150016 Show fit	0.91	ENST00000375854.3 ENST00000375855.3	NXNL2 Ensembl NCBI GeneCards UniProt Show fit	nucleoredoxin-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.3	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.1	3.6	GO:0070911	global genome nucleotide-excision repair(GO:0070911)
0.1	3.1	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1	2.8	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	2.7	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	2.7	GO:0010389	regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1	2.6	GO:0032486	Rap protein signal transduction(GO:0032486)
0.2	2.4	GO:0015693	magnesium ion transport(GO:0015693)
0.7	2.2	GO:1903461	Okazaki fragment processing involved in mitotic DNA replication(GO:1903461)
0.4	2.2	GO:0030421	defecation(GO:0030421)

Showing 1 to 10 of 1,281 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.1	GO:0044309	neuron spine(GO:0044309)
0.1	5.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	3.3	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	3.1	GO:0070822	Sin3-type complex(GO:0070822)
0.0	3.1	GO:0031091	platelet alpha granule(GO:0031091)
0.0	3.0	GO:0000776	kinetochore(GO:0000776)
0.0	2.8	GO:0032587	ruffle membrane(GO:0032587)
0.2	2.7	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	2.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	2.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Showing 1 to 10 of 416 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	4.6	GO:0019003	GDP binding(GO:0019003)
0.4	4.3	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	4.0	GO:0042393	histone binding(GO:0042393)
0.0	3.5	GO:0005516	calmodulin binding(GO:0005516)
0.1	3.4	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	3.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	3.3	GO:0035064	methylated histone binding(GO:0035064)
0.0	3.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	2.9	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 703 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	4.8	PID BMP PATHWAY	BMP receptor signaling
0.1	4.7	PID RAS PATHWAY	Regulation of Ras family activation
0.1	4.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	3.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	3.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	3.0	PID PLK1 PATHWAY	PLK1 signaling events
0.1	2.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	2.5	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	2.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 95 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.0	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.2	5.2	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1	3.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	3.2	REACTOME EARLY PHASE OF HIV LIFE CYCLE	Genes involved in Early Phase of HIV Life Cycle
0.0	3.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.9	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events
0.1	2.8	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	2.7	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	2.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	2.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Showing 1 to 10 of 182 entries

Results for WT1_MTF1_ZBTB7B

Z-value: 1.36

Motif logo

Transcription factors associated with WT1_MTF1_ZBTB7B

Activity-expression correlation:

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: