ISMARA results: WRNIP1

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for WRNIP1

Z-value: 2.10

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Transcription factors associated with WRNIP1

Gene Symbol	Gene ID	Gene Info
WRNIP1 Ensembl NCBI GeneCards UniProt	ENSG00000124535.11	WRN helicase interacting protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WRNIP1	hg19_v2_chr6_+_2765595_2765797	0.78	2.2e-01	Click!

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_51152702 Show fit	5.42	ENST00000425202.1	C19orf81 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 81
chr4_+_76649753 Show fit	3.53	ENST00000603759.1	USO1 Ensembl NCBI GeneCards UniProt Show fit	USO1 vesicle transport factor
chr5_+_175298674 Show fit	2.23	ENST00000514150.1	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr16_+_30709530 Show fit	2.16	ENST00000411466.2	SRCAP Ensembl NCBI GeneCards UniProt Show fit	Snf2-related CREBBP activator protein
chr5_+_175298573 Show fit	2.09	ENST00000512824.1	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr19_+_48673949 Show fit	1.74	ENST00000328759.7	C19orf68 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 68
chr11_+_71934962 Show fit	1.65	ENST00000543234.1	INPPL1 Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate phosphatase-like 1
chr8_+_21906433 Show fit	1.58	ENST00000522148.1	DMTN Ensembl NCBI GeneCards UniProt Show fit	dematin actin binding protein
chr5_+_175298487 Show fit	1.55	ENST00000393745.3	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr19_-_46272462 Show fit	1.53	ENST00000317578.6	SIX5 Ensembl NCBI GeneCards UniProt Show fit	SIX homeobox 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.2	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.3	5.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	3.6	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.1	3.5	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.4	3.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.3	3.0	GO:0030259	lipid glycosylation(GO:0030259)
0.2	2.9	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.7	2.8	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.2	2.8	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2	2.7	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)

Showing 1 to 10 of 1,031 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	7.1	GO:0070554	synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1	4.9	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	4.4	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	4.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	2.9	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	2.8	GO:0005581	collagen trimer(GO:0005581)
0.1	2.7	GO:0038201	TOR complex(GO:0038201)
0.0	2.7	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2	2.4	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)
0.1	2.2	GO:0098533	cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533)

Showing 1 to 10 of 299 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	5.8	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4	5.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1	3.4	GO:0017091	AU-rich element binding(GO:0017091)
0.1	3.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3	3.2	GO:0019826	oxygen sensor activity(GO:0019826)
0.7	2.8	GO:0001632	leukotriene B4 receptor activity(GO:0001632) leukotriene receptor activity(GO:0004974)
0.4	2.5	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	2.5	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.0	2.5	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Showing 1 to 10 of 610 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	3.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.8	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	2.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	2.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	2.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	2.0	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	2.0	PID P53 REGULATION PATHWAY	p53 pathway

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	3.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	3.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	2.9	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	2.9	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.9	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	2.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	2.6	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	2.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 100 entries

Results for WRNIP1

Z-value: 2.10

Motif logo

Transcription factors associated with WRNIP1

Activity-expression correlation:

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: