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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.86
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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000105967.11 | transcription factor EC | |
| ENSG00000187098.10 | melanocyte inducing transcription factor | |
| ENSG00000133794.13 | aryl hydrocarbon receptor nuclear translocator like | |
| ENSG00000123095.5 | basic helix-loop-helix family member e41 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MITF | hg19_v2_chr3_+_69985792_69985874 | -0.89 | 1.1e-01 | Click! |
| ARNTL | hg19_v2_chr11_+_13299186_13299432 | -0.77 | 2.3e-01 | Click! |
| BHLHE41 | hg19_v2_chr12_-_26278030_26278060 | 0.35 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.3 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.1 | 2.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 2.2 | GO:0090520 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.5 | 2.1 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.6 | 1.7 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.0 | 1.6 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.2 | 1.4 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.3 | 1.3 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.0 | 1.3 | GO:0034724 | DNA replication-independent nucleosome organization(GO:0034724) |
| 0.2 | 1.2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 1.8 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.3 | 1.3 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.1 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 0.9 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.1 | 0.9 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.1 | 0.7 | GO:0097413 | Lewy body(GO:0097413) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 2.4 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 2.3 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.4 | 2.1 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.0 | 1.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 1.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.6 | 1.7 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.0 | 1.5 | GO:0004521 | endoribonuclease activity(GO:0004521) |
| 0.3 | 1.3 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 1.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.0 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 0.9 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.8 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |