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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for TFAP2E

Z-value: 0.71

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_360389710.762.4e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_27112380 0.35 ENST00000554596.1
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr15_+_27112194 0.32 ENST00000555182.1
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr19_+_54960790 0.30 ENST00000443957.1
leukocyte receptor cluster (LRC) member 8
chr15_+_27112251 0.27 ENST00000400081.3
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr11_+_63974135 0.25 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
fermitin family member 3
chr15_+_27112296 0.25 ENST00000554038.1
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr1_+_17634689 0.24 ENST00000375453.1
ENST00000375448.4
peptidyl arginine deiminase, type IV
chr11_-_65625014 0.23 ENST00000534784.1
cofilin 1 (non-muscle)
chr11_+_66045634 0.23 ENST00000528852.1
ENST00000311445.6
cornichon family AMPA receptor auxiliary protein 2
chr9_-_21077939 0.22 ENST00000380232.2
interferon, beta 1, fibroblast
chr20_+_36888551 0.21 ENST00000418004.1
ENST00000451435.1
bactericidal/permeability-increasing protein
chr15_+_27112058 0.21 ENST00000355395.5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr16_-_72698834 0.21 ENST00000570152.1
ENST00000561611.2
ENST00000570035.1
AC004158.2
chr10_-_112678692 0.21 ENST00000605742.1
BBSome interacting protein 1
chr1_+_9599540 0.21 ENST00000302692.6
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr3_+_105086056 0.21 ENST00000472644.2
activated leukocyte cell adhesion molecule
chr17_-_42188598 0.20 ENST00000591714.1
histone deacetylase 5
chr10_-_112678904 0.20 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBSome interacting protein 1
chr5_-_179719048 0.19 ENST00000523583.1
ENST00000393360.3
ENST00000455781.1
ENST00000347470.4
ENST00000452135.2
ENST00000343111.6
mitogen-activated protein kinase 9
chr9_-_86432547 0.18 ENST00000376365.3
ENST00000376371.2
G kinase anchoring protein 1
chr12_+_75784850 0.18 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLI pathogenesis-related 1 like 2
chr22_+_35653445 0.18 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr17_-_31620006 0.18 ENST00000225823.2
acid-sensing (proton-gated) ion channel 2
chr7_-_140624499 0.18 ENST00000288602.6
v-raf murine sarcoma viral oncogene homolog B
chr1_+_211433275 0.17 ENST00000367005.4
REST corepressor 3
chr10_-_112678976 0.17 ENST00000448814.1
BBSome interacting protein 1
chr4_+_154387480 0.17 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
chr2_-_174828892 0.16 ENST00000418194.2
Sp3 transcription factor
chr7_-_23053719 0.16 ENST00000432176.2
ENST00000440481.1
family with sequence similarity 126, member A
chrX_+_115567767 0.15 ENST00000371900.4
solute carrier family 6 (amino acid transporter), member 14
chr17_+_29158962 0.15 ENST00000321990.4
ATPase family, AAA domain containing 5
chr8_+_17780346 0.14 ENST00000325083.8
pericentriolar material 1
chr11_-_47870019 0.14 ENST00000378460.2
nucleoporin 160kDa
chr2_-_241831424 0.13 ENST00000402775.2
ENST00000307486.8
chromosome 2 open reading frame 54
chr8_+_17780483 0.13 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
pericentriolar material 1
chr20_+_55205825 0.13 ENST00000544508.1
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr2_+_233243233 0.13 ENST00000392027.2
alkaline phosphatase, placental
chr3_+_110790590 0.13 ENST00000485303.1
poliovirus receptor-related 3
chrX_+_131157290 0.12 ENST00000394334.2
Serine/threonine-protein kinase MST4
chrX_+_131157322 0.12 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
Serine/threonine-protein kinase MST4
chr1_+_43148625 0.12 ENST00000436427.1
Y box binding protein 1
chr1_+_104068562 0.12 ENST00000423855.2
RNA-binding region (RNP1, RRM) containing 3
chr12_-_75784669 0.12 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
calcyphosine 2
chr1_+_104068312 0.11 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNA-binding region (RNP1, RRM) containing 3
chr2_+_74741569 0.11 ENST00000233638.7
T-cell leukemia homeobox 2
chr9_+_19230433 0.11 ENST00000434457.2
ENST00000602925.1
DENN/MADD domain containing 4C
chr3_-_128207349 0.11 ENST00000487848.1
GATA binding protein 2
chr1_-_154531095 0.10 ENST00000292211.4
ubiquitin-conjugating enzyme E2Q family member 1
chr16_+_69600058 0.10 ENST00000393742.2
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_-_179499108 0.10 ENST00000521389.1
ring finger protein 130
chr5_-_179498703 0.10 ENST00000522208.2
ring finger protein 130
chr10_-_98480243 0.09 ENST00000339364.5
phosphoinositide-3-kinase adaptor protein 1
chr7_-_23053693 0.09 ENST00000409763.1
ENST00000409923.1
family with sequence similarity 126, member A
chr6_+_150070857 0.09 ENST00000544496.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr16_+_69599899 0.09 ENST00000567239.1
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_35225339 0.09 ENST00000339480.1
gap junction protein, beta 4, 30.3kDa
chr3_+_50192833 0.09 ENST00000426511.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr6_+_13272904 0.09 ENST00000379335.3
ENST00000379329.1
phosphatase and actin regulator 1
chr14_-_25519095 0.09 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
syntaxin binding protein 6 (amisyn)
chr2_-_45236540 0.09 ENST00000303077.6
SIX homeobox 2
chr12_-_15942503 0.08 ENST00000281172.5
epidermal growth factor receptor pathway substrate 8
chr5_+_133984462 0.08 ENST00000398844.2
ENST00000322887.4
SEC24 family member A
chr4_-_85419603 0.08 ENST00000295886.4
NK6 homeobox 1
chr4_-_82393009 0.08 ENST00000436139.2
RasGEF domain family, member 1B
chr4_+_75480629 0.08 ENST00000380846.3
amphiregulin B
chr17_+_40932610 0.08 ENST00000246914.5
WNK lysine deficient protein kinase 4
chr3_+_4535155 0.08 ENST00000544951.1
inositol 1,4,5-trisphosphate receptor, type 1
chr17_-_42992856 0.08 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
glial fibrillary acidic protein
chr3_+_4535025 0.08 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
inositol 1,4,5-trisphosphate receptor, type 1
chr2_+_75061108 0.08 ENST00000290573.2
hexokinase 2
chr5_-_115152651 0.07 ENST00000250535.4
cysteine dioxygenase type 1
chr5_-_151304337 0.07 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
glycine receptor, alpha 1
chr10_+_99894380 0.07 ENST00000370584.3
R3H domain and coiled-coil containing 1-like
chr11_+_82612740 0.07 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
chromosome 11 open reading frame 82
chr17_-_47755436 0.07 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr19_-_43969796 0.07 ENST00000244333.3
LY6/PLAUR domain containing 3
chr11_-_47869865 0.07 ENST00000530326.1
ENST00000532747.1
nucleoporin 160kDa
chr22_+_38146987 0.07 ENST00000418339.1
TRIO and F-actin binding protein
chrX_+_152783131 0.06 ENST00000349466.2
ENST00000370186.1
ATPase, Ca++ transporting, plasma membrane 3
chrX_+_49028265 0.06 ENST00000376322.3
ENST00000376327.5
proteolipid protein 2 (colonic epithelium-enriched)
chr22_+_31608219 0.06 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIM domain kinase 2
chr17_-_47755338 0.06 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
speckle-type POZ protein
chr1_+_76540386 0.06 ENST00000328299.3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr16_+_69599861 0.06 ENST00000354436.2
nuclear factor of activated T-cells 5, tonicity-responsive
chr11_-_35441524 0.06 ENST00000395750.1
ENST00000449068.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr20_+_58508817 0.06 ENST00000358293.3
family with sequence similarity 217, member B
chrX_-_118826784 0.05 ENST00000394616.4
septin 6
chr3_+_171757346 0.05 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
fibronectin type III domain containing 3B
chr14_+_77607026 0.05 ENST00000600936.1
Uncharacterized protein; cDNA FLJ43210 fis, clone FEBRA2020582
chr6_+_150070831 0.05 ENST00000367380.5
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_228194693 0.05 ENST00000284523.1
ENST00000366753.2
wingless-type MMTV integration site family, member 3A
chr22_+_31644388 0.05 ENST00000333611.4
ENST00000340552.4
LIM domain kinase 2
chr10_+_99894399 0.05 ENST00000298999.3
ENST00000314594.5
R3H domain and coiled-coil containing 1-like
chr2_-_24149977 0.05 ENST00000238789.5
ATPase family, AAA domain containing 2B
chr9_+_136501478 0.05 ENST00000393056.2
ENST00000263611.2
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr6_+_292051 0.04 ENST00000344450.5
dual specificity phosphatase 22
chr22_+_31644309 0.04 ENST00000425203.1
LIM domain kinase 2
chr13_-_76056250 0.04 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1 domain family, member 4
chr10_-_108924284 0.04 ENST00000344440.6
ENST00000263054.6
sortilin-related VPS10 domain containing receptor 1
chr5_-_179499086 0.04 ENST00000261947.4
ring finger protein 130
chr10_+_102505954 0.04 ENST00000556085.1
ENST00000427256.1
paired box 2
chr12_+_57984965 0.04 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr9_+_128024067 0.04 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
GTPase activating protein and VPS9 domains 1
chr19_-_39264072 0.04 ENST00000599035.1
ENST00000378626.4
lectin, galactoside-binding, soluble, 7
chr4_+_41992489 0.04 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr19_+_45504688 0.04 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr19_+_36195429 0.04 ENST00000392197.2
zinc finger and BTB domain containing 32
chr1_-_114355083 0.04 ENST00000261441.5
round spermatid basic protein 1
chr15_-_65503801 0.04 ENST00000261883.4
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr3_-_136471204 0.04 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
stromal antigen 1
chr17_+_74070853 0.04 ENST00000329003.3
galanin receptor 2
chr17_-_39769005 0.04 ENST00000301653.4
ENST00000593067.1
keratin 16
chr10_-_98273668 0.03 ENST00000357947.3
tolloid-like 2
chr6_+_42531798 0.03 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
ubiquitin protein ligase E3 component n-recognin 2
chr3_-_55521323 0.03 ENST00000264634.4
wingless-type MMTV integration site family, member 5A
chr3_-_48130314 0.03 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
microtubule-associated protein 4
chr13_-_27334879 0.03 ENST00000405846.3
G protein-coupled receptor 12
chr14_-_64010046 0.03 ENST00000337537.3
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_-_35440796 0.03 ENST00000278379.3
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr20_-_13619550 0.02 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
taspase, threonine aspartase, 1
chr1_-_151778630 0.02 ENST00000368820.3
leucine rich repeat and Ig domain containing 4
chr4_-_101439242 0.02 ENST00000296420.4
endomucin
chr19_+_3572758 0.02 ENST00000416526.1
high mobility group 20B
chr5_+_176237478 0.02 ENST00000329542.4
unc-5 homolog A (C. elegans)
chr2_-_133429091 0.02 ENST00000345008.6
LY6/PLAUR domain containing 1
chr8_+_146277764 0.01 ENST00000331434.6
chromosome 8 open reading frame 33
chr6_+_99282570 0.01 ENST00000328345.5
POU class 3 homeobox 2
chr14_-_64010006 0.01 ENST00000555899.1
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_-_37551846 0.01 ENST00000443187.1
protein kinase D3
chr11_-_71752838 0.01 ENST00000537930.1
nuclear mitotic apparatus protein 1
chr12_-_15942309 0.00 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
epidermal growth factor receptor pathway substrate 8
chr14_-_25519317 0.00 ENST00000323944.5
syntaxin binding protein 6 (amisyn)
chr11_-_47870091 0.00 ENST00000526870.1
nucleoporin 160kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.2 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.2 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.0 1.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.3 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0035854 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.0 GO:0090381 positive regulation of cell fate specification(GO:0042660) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0090188 negative regulation of pancreatic juice secretion(GO:0090188)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0042412 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) taurine biosynthetic process(GO:0042412) L-cysteine metabolic process(GO:0046439)
0.0 0.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:0030047 actin modification(GO:0030047)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:1904925 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 1.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway