ISMARA results: TFAP2C

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for TFAP2C

Z-value: 1.60

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Transcription factors associated with TFAP2C

Gene Symbol	Gene ID	Gene Info
TFAP2C Ensembl NCBI GeneCards UniProt	ENSG00000087510.5	transcription factor AP-2 gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFAP2C	hg19_v2_chr20_+_55204351_55204377	0.79	2.1e-01	Click!

Activity profile of TFAP2C motif

Sorted Z-values of TFAP2C motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_145734433 Show fit	1.09	ENST00000301327.4	MFSD3 Ensembl NCBI GeneCards UniProt Show fit	major facilitator superfamily domain containing 3
chr3_-_9834463 Show fit	1.05	ENST00000439043.1	TADA3 Ensembl NCBI GeneCards UniProt Show fit	transcriptional adaptor 3
chr5_+_149865377 Show fit	0.99	ENST00000522491.1	NDST1 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr8_+_22428457 Show fit	0.97	ENST00000517962.1	SORBS3 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 3
chr15_+_41786065 Show fit	0.83	ENST00000260386.5	ITPKA Ensembl NCBI GeneCards UniProt Show fit	inositol-trisphosphate 3-kinase A
chr11_+_2920951 Show fit	0.82	ENST00000347936.2	SLC22A18 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22, member 18
chr16_-_28223229 Show fit	0.81	ENST00000566073.1	XPO6 Ensembl NCBI GeneCards UniProt Show fit	exportin 6
chrX_+_153238220 Show fit	0.77	ENST00000425274.1	TMEM187 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 187
chr9_-_139010696 Show fit	0.74	ENST00000418388.1 ENST00000561457.1	C9orf69 Ensembl NCBI GeneCards UniProt Show fit	chromosome 9 open reading frame 69
chr2_-_74692473 Show fit	0.74	ENST00000535045.1 ENST00000409065.1 ENST00000414701.1 ENST00000448666.1 ENST00000233616.4 ENST00000452063.2	MOGS Ensembl NCBI GeneCards UniProt Show fit	mannosyl-oligosaccharide glucosidase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2C

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0007141	male meiosis I(GO:0007141)
0.1	1.7	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	1.3	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	1.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	1.2	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2	1.1	GO:0097403	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1	1.1	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.1	1.1	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.3	1.0	GO:0043181	vacuolar sequestering(GO:0043181)
0.2	1.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)

Showing 1 to 10 of 452 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0043202	lysosomal lumen(GO:0043202)
0.0	2.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	2.1	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	1.9	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	1.4	GO:0038201	TOR complex(GO:0038201)
0.1	1.1	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	1.1	GO:0005581	collagen trimer(GO:0005581)
0.1	1.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	1.0	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.9	GO:0045323	interleukin-1 receptor complex(GO:0045323)

Showing 1 to 10 of 113 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	1.6	GO:0017166	vinculin binding(GO:0017166)
0.0	1.5	GO:0017091	AU-rich element binding(GO:0017091)
0.0	1.4	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	1.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.1	1.3	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2	1.1	GO:0050119	N-acetylglucosamine deacetylase activity(GO:0050119)
0.0	1.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	1.1	GO:0050699	WW domain binding(GO:0050699)
0.0	1.1	GO:0003707	steroid hormone receptor activity(GO:0003707)

Showing 1 to 10 of 285 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.6	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.9	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	0.8	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.8	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.7	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	2.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.6	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	1.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	1.5	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	1.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.2	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	1.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	1.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Showing 1 to 10 of 53 entries

Results for TFAP2C

Z-value: 1.60

Motif logo

Transcription factors associated with TFAP2C

Activity-expression correlation:

Activity profile of TFAP2C motif

Sorted Z-values of TFAP2C motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2C

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: