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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for TCF7
Z-value: 1.44
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Transcription factors associated with TCF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7 | hg19_v2_chr5_+_133450365_133450444 | -0.97 | 3.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_57229155 Show fit | 0.55 |
ENST00000584089.1
|
spindle and kinetochore associated complex subunit 2 |
|
| chrX_-_148676974 Show fit | 0.53 |
ENST00000524178.1
|
heat shock transcription factor family, X linked 2 |
|
| chr9_-_21077939 Show fit | 0.52 |
ENST00000380232.2
|
interferon, beta 1, fibroblast |
|
| chr1_+_200993071 Show fit | 0.49 |
ENST00000446333.1
ENST00000458003.1 |
RP11-168O16.1 |
|
| chrX_-_55020511 Show fit | 0.49 |
ENST00000375006.3
ENST00000374992.2 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
|
| chr15_+_36871983 Show fit | 0.49 |
ENST00000437989.2
ENST00000569302.1 |
chromosome 15 open reading frame 41 |
|
| chr5_+_136070614 Show fit | 0.48 |
ENST00000502421.1
|
CTB-1I21.1 |
|
| chrX_+_148855726 Show fit | 0.45 |
ENST00000370416.4
|
heat shock transcription factor family, X linked 1 |
|
| chr12_+_8849773 Show fit | 0.45 |
ENST00000541044.1
|
ribosomal modification protein rimK-like family member B |
|
| chr12_-_49582593 Show fit | 0.45 |
ENST00000295766.5
|
tubulin, alpha 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.2 | 0.5 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 0.1 | 0.5 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.1 | 0.5 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.5 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 0.4 | GO:0021718 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.1 | 0.4 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 0.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.4 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 0.4 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.8 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 0.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.6 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 0.4 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 0.4 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 0.3 | GO:1990769 | proximal neuron projection(GO:1990769) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.2 | 0.5 | GO:0072591 | citrate-L-glutamate ligase activity(GO:0072591) |
| 0.1 | 0.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.5 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 0.4 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.1 | 0.4 | GO:0001855 | complement component C4b binding(GO:0001855) |
| 0.1 | 0.4 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.9 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 0.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |