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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for TCF12_ASCL2
Z-value: 1.90
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Transcription factors associated with TCF12_ASCL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF12 | hg19_v2_chr15_+_57210961_57211030 | -0.89 | 1.1e-01 | Click! |
| ASCL2 | hg19_v2_chr11_-_2292182_2292212 | 0.66 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF12_ASCL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.5 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.0 | 3.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 3.4 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 3.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.7 | 2.6 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
| 0.4 | 2.3 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.1 | 2.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 2.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 2.0 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 1.9 | GO:0007386 | compartment pattern specification(GO:0007386) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 3.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.3 | 2.8 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 2.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.4 | 2.6 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.1 | 2.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.4 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 1.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 1.5 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 3.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 2.7 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.1 | 2.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 2.3 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.1 | 2.0 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 2.0 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 2.0 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.5 | 1.6 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.3 | 1.6 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.2 | 2.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 2.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.9 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 1.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |