ISMARA results: TBX3

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for TBX3

Z-value: 0.82

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Transcription factors associated with TBX3

Gene Symbol	Gene ID	Gene Info
TBX3 Ensembl NCBI GeneCards UniProt	ENSG00000135111.10	T-box transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX3	hg19_v2_chr12_-_115121962_115121987	0.43	5.7e-01	Click!

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_34679725 Show fit	0.76	ENST00000432589.1	EPB41L1 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.1-like 1
chr19_+_50148087 Show fit	0.69	ENST00000601038.1 ENST00000595242.1	SCAF1 Ensembl NCBI GeneCards UniProt Show fit	SR-related CTD-associated factor 1
chr3_+_149192475 Show fit	0.59	ENST00000465758.1	TM4SF4 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 4 L six family member 4
chr19_-_47735918 Show fit	0.45	ENST00000449228.1 ENST00000300880.7 ENST00000341983.4	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr17_+_39411636 Show fit	0.40	ENST00000394008.1	KRTAP9-9 Ensembl NCBI GeneCards UniProt Show fit	keratin associated protein 9-9
chr19_-_10679697 Show fit	0.38	ENST00000335766.2	CDKN2D Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_+_20483037 Show fit	0.38	ENST00000399044.1	CDRT15L2 Ensembl NCBI GeneCards UniProt Show fit	CMT1A duplicated region transcript 15-like 2
chr17_+_75396637 Show fit	0.33	ENST00000590825.1	SEPT9 Ensembl NCBI GeneCards UniProt Show fit	septin 9
chr19_-_10679644 Show fit	0.32	ENST00000393599.2	CDKN2D Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr15_+_79603479 Show fit	0.32	ENST00000424155.2 ENST00000536821.1	TMED3 Ensembl NCBI GeneCards UniProt Show fit	transmembrane emp24 protein transport domain containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0048102	autophagic cell death(GO:0048102)
0.0	0.6	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.5	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.1	0.3	GO:0061143	alveolar primary septum development(GO:0061143)
0.0	0.3	GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692)
0.0	0.3	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.3	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.3	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1	0.2	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)

Showing 1 to 10 of 41 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	0.5	GO:0030126	COPI vesicle coat(GO:0030126)
0.1	0.3	GO:0032044	DSIF complex(GO:0032044)
0.1	0.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.3	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.2	GO:0097179	protease inhibitor complex(GO:0097179)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	0.2	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0070931	Golgi-associated vesicle lumen(GO:0070931)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.5	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.5	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.3	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	0.2	GO:0033878	hormone-sensitive lipase activity(GO:0033878)
0.1	0.2	GO:0004947	bradykinin receptor activity(GO:0004947)
0.0	0.2	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0	0.2	GO:0004936	alpha-adrenergic receptor activity(GO:0004936)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.8	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.5	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones

Showing 1 to 7 of 7 entries

Results for TBX3

Z-value: 0.82

Motif logo

Transcription factors associated with TBX3

Activity-expression correlation:

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: