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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for TAL1
Z-value: 1.09
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Transcription factors associated with TAL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAL1 | hg19_v2_chr1_-_47697387_47697457 | 0.14 | 8.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_91061712 Show fit | 0.72 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr19_-_39735646 Show fit | 0.69 |
ENST00000413851.2
|
interferon, lambda 3 |
|
| chr22_+_22556057 Show fit | 0.65 |
ENST00000390286.2
|
immunoglobulin lambda variable 11-55 (non-functional) |
|
| chr16_+_23847339 Show fit | 0.46 |
ENST00000303531.7
|
protein kinase C, beta |
|
| chr11_-_10920838 Show fit | 0.43 |
ENST00000503469.2
|
CTD-2003C8.2 |
|
| chr16_-_81110683 Show fit | 0.43 |
ENST00000565253.1
ENST00000378611.4 ENST00000299578.5 |
chromosome 16 open reading frame 46 |
|
| chr17_-_79623597 Show fit | 0.40 |
ENST00000574024.1
ENST00000331056.5 |
phosphodiesterase 6G, cGMP-specific, rod, gamma |
|
| chr19_-_38743878 Show fit | 0.40 |
ENST00000587515.1
|
protein phosphatase 1, regulatory (inhibitor) subunit 14A |
|
| chr1_+_161494036 Show fit | 0.37 |
ENST00000309758.4
|
heat shock 70kDa protein 6 (HSP70B') |
|
| chr10_-_46342675 Show fit | 0.37 |
ENST00000492347.1
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.0 | 0.9 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.1 | 0.7 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.1 | 0.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 0.7 | GO:0010917 | negative regulation of mitochondrial membrane potential(GO:0010917) |
| 0.0 | 0.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.6 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
| 0.0 | 0.6 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 0.6 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 0.5 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.5 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.7 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.6 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.2 | 0.5 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.1 | 0.5 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 0.5 | GO:0044594 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594) |
| 0.0 | 0.5 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.0 | 0.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.0 | 1.2 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 1.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.7 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 0.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |