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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SREBF2

Z-value: 0.17

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.386.2e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_6659876 0.06 ENST00000496707.1
KLHL21
kelch-like family member 21
chr19_-_55791058 0.06 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr1_+_55505184 0.05 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr3_-_171527560 0.05 ENST00000331659.2
PP13439
PP13439
chr6_-_32151999 0.05 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr11_+_2923619 0.04 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr11_+_2923423 0.04 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr5_+_137774706 0.04 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr1_-_155232221 0.04 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chrX_-_153236819 0.03 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr20_+_33464368 0.03 ENST00000484354.1
ENST00000493805.2
ENST00000473172.1
ACSS2
acyl-CoA synthetase short-chain family member 2
chr11_+_65383227 0.03 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chrX_+_47229982 0.03 ENST00000377073.3
ZNF157
zinc finger protein 157
chr16_+_8736232 0.03 ENST00000562973.1
METTL22
methyltransferase like 22
chr15_-_73075964 0.03 ENST00000563907.1
ADPGK
ADP-dependent glucokinase
chrX_-_153236620 0.03 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_56150184 0.02 ENST00000394554.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr17_-_17726907 0.02 ENST00000423161.3
SREBF1
sterol regulatory element binding transcription factor 1
chr6_+_79577189 0.02 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chrX_-_153237258 0.02 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr7_-_44580861 0.02 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr2_+_27435734 0.02 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr11_+_2923499 0.02 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr17_+_65040678 0.02 ENST00000226021.3
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chr19_-_46285646 0.02 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr1_+_206643787 0.02 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr12_-_53343602 0.02 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr22_+_42229100 0.02 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr1_+_33219592 0.02 ENST00000373481.3
KIAA1522
KIAA1522
chr19_-_18392422 0.02 ENST00000252818.3
JUND
jun D proto-oncogene
chr4_-_54930790 0.02 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr11_+_22688150 0.02 ENST00000454584.2
GAS2
growth arrest-specific 2
chr1_-_155232047 0.02 ENST00000302631.3
SCAMP3
secretory carrier membrane protein 3
chr12_-_53343633 0.01 ENST00000546826.1
KRT8
keratin 8
chr16_+_2083265 0.01 ENST00000565855.1
ENST00000566198.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr2_-_26205340 0.01 ENST00000264712.3
KIF3C
kinesin family member 3C
chr20_+_33464407 0.01 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr18_-_21166841 0.01 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr12_-_53343560 0.01 ENST00000548998.1
KRT8
keratin 8
chr6_+_43968306 0.01 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr6_+_41604747 0.01 ENST00000419164.1
ENST00000373051.2
MDFI
MyoD family inhibitor
chr6_-_42713792 0.01 ENST00000372876.1
TBCC
tubulin folding cofactor C
chr19_-_46285736 0.01 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr17_-_73257667 0.01 ENST00000538886.1
ENST00000580799.1
ENST00000351904.7
ENST00000537686.1
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr3_+_188889737 0.01 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr6_+_41604620 0.01 ENST00000432027.1
MDFI
MyoD family inhibitor
chr3_-_16554403 0.01 ENST00000449415.1
ENST00000441460.1
RFTN1
raftlin, lipid raft linker 1
chr15_-_73076030 0.01 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr19_+_38664224 0.01 ENST00000601054.1
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr20_+_33464238 0.01 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr16_+_31225337 0.01 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr9_+_126131131 0.01 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr19_+_11200038 0.01 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr14_-_74959978 0.01 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr1_+_206643806 0.01 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr14_+_74960423 0.01 ENST00000556816.1
ENST00000298818.8
ENST00000554924.1
ISCA2
iron-sulfur cluster assembly 2
chr6_-_32152064 0.01 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr3_+_5020801 0.01 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr1_-_42384343 0.01 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr6_-_52859968 0.01 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr3_-_98620500 0.01 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr12_+_56495115 0.01 ENST00000548861.1
RP11-603J24.9
Uncharacterized protein
chr20_+_58533471 0.01 ENST00000244047.5
ENST00000348616.4
CDH26
cadherin 26
chr5_-_107703556 0.01 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr1_+_197237352 0.01 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr17_-_27332931 0.01 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr2_-_26205550 0.01 ENST00000405914.1
KIF3C
kinesin family member 3C
chr16_+_50187556 0.00 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr8_+_104512976 0.00 ENST00000504942.2
RIMS2
regulating synaptic membrane exocytosis 2
chr11_+_65480222 0.00 ENST00000534681.1
KAT5
K(lysine) acetyltransferase 5
chr4_+_75230853 0.00 ENST00000244869.2
EREG
epiregulin
chr9_+_131451480 0.00 ENST00000322030.8
SET
SET nuclear oncogene
chr6_+_42141029 0.00 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chrX_-_112084043 0.00 ENST00000304758.1
AMOT
angiomotin

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.1 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.1 GO:0046618 drug export(GO:0046618)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:1904599 advanced glycation end-product binding(GO:1904599)