ISMARA results: SP4

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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SP4_PML

Z-value: 1.50

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Transcription factors associated with SP4_PML

Gene Symbol	Gene ID	Gene Info
SP4 Ensembl NCBI GeneCards UniProt	ENSG00000105866.9	Sp4 transcription factor
PML Ensembl NCBI GeneCards UniProt	ENSG00000140464.15	PML nuclear body scaffold

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PML	hg19_v2_chr15_+_74287118_74287144	0.73	2.7e-01	Click!
SP4	hg19_v2_chr7_+_21467642_21467671	-0.59	4.1e-01	Click!

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_14396121 Show fit	2.15	ENST00000570945.1	RP11-65J21.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-65J21.3
chr6_+_12012170 Show fit	1.77	ENST00000487103.1	HIVEP1 Ensembl NCBI GeneCards UniProt Show fit	human immunodeficiency virus type I enhancer binding protein 1
chr4_+_6784358 Show fit	1.45	ENST00000508423.1	KIAA0232 Ensembl NCBI GeneCards UniProt Show fit	KIAA0232
chr11_-_568369 Show fit	1.42	ENST00000534540.1 ENST00000528245.1 ENST00000500447.1 ENST00000533920.1	MIR210HG Ensembl NCBI GeneCards UniProt Show fit	MIR210 host gene (non-protein coding)
chr14_+_21566980 Show fit	1.23	ENST00000418511.2 ENST00000554329.2	TMEM253 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 253
chr6_-_163834852 Show fit	1.23	ENST00000604200.1	CAHM Ensembl NCBI GeneCards UniProt Show fit	colon adenocarcinoma hypermethylated (non-protein coding)
chr16_+_50280020 Show fit	1.23	ENST00000564965.1	ADCY7 Ensembl NCBI GeneCards UniProt Show fit	adenylate cyclase 7
chr12_-_80084594 Show fit	1.14	ENST00000548426.1	PAWR Ensembl NCBI GeneCards UniProt Show fit	PRKC, apoptosis, WT1, regulator
chr7_+_97910962 Show fit	1.11	ENST00000539286.1	BRI3 Ensembl NCBI GeneCards UniProt Show fit	brain protein I3
chr4_+_2061119 Show fit	1.05	ENST00000423729.2	NAT8L Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 8-like (GCN5-related, putative)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.3	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0	1.9	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	1.7	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.2	1.6	GO:1902613	regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1	1.6	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.1	1.6	GO:0071361	cellular response to ethanol(GO:0071361)
0.2	1.5	GO:1901315	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1	1.5	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1	1.5	GO:0034063	stress granule assembly(GO:0034063)
0.1	1.5	GO:0000185	activation of MAPKKK activity(GO:0000185)

Showing 1 to 10 of 968 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	2.2	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	2.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	1.6	GO:0000421	autophagosome membrane(GO:0000421)
0.1	1.5	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	1.5	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	1.4	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	1.4	GO:0097546	ciliary base(GO:0097546)
0.0	1.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	1.3	GO:0070554	synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Showing 1 to 10 of 292 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0030275	LRR domain binding(GO:0030275)
0.0	3.0	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	2.4	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	2.4	GO:0008565	protein transporter activity(GO:0008565)
0.0	2.4	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	2.3	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.1	2.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1	2.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	2.2	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	2.0	GO:0071889	14-3-3 protein binding(GO:0071889)

Showing 1 to 10 of 548 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	2.2	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	2.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	1.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.6	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 53 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	2.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	2.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.0	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.1	1.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	1.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	1.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.1	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA

Showing 1 to 10 of 81 entries

Results for SP4_PML

Z-value: 1.50

Motif logo

Transcription factors associated with SP4_PML

Activity-expression correlation:

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: